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EC number: 202-075-7 | CAS number: 91-53-2
Estimation of the actual intakes of ethoxyquin in this study was confounded by up to twofold increased consumption during lactation and the fact that 180 and 360 ppm had to be added to obtain nominal concentrations of 150 and 300 ppm, however, the analysis showed mean initial values of 100 and 225 ppm. Although the actual amounts of food consumed varied during the study, a value of 25 g/kg bw per day was considered to be a representative mean, which resulted in intakes of 2.5 mg/kg bw per day ethxyquin at 100 ppm and 5.6 mg/kg bw per day at 225 ppm.
Reproduction effects of ethoxyquin were investigated in a two-generation study in dogs. In this study, reproduction was not altered at the upper dose level of 225 ppm corresponding to a mean daily intake of 5.6 mg/kg bw. Accordingly, the reproductive NOAEL can be set at (or even above) 5.6 mg/kg bw/day. In contrast, there was no clear overall NOAEL for parental toxicity in that study because of increased incidences of clinical signs such as excess lachrymation and dehydration, clinical chemical changes and pigment deposition in the liver that were still seen at the lowest dose of 100 ppm, equal to 2.5 mg/kg bw per day. Adult dogs in both the F0 and F1 generations were affected. Thus, this dose was considered the LOAEL for parental and offspring toxicity as well.
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