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EC number: 202-075-7 | CAS number: 91-53-2
The test article did not cause an increase in the mean number of revertants per plate with any of the tester strains either in the presence or absence of microsomal enzymes (S9). The positive control substances gave the expected increase in mutant frequencies.
In a reverse gene mutation assay in bacteria (OECD 471), Salmonella typhimuriumtest strains TA98, TA100, TA1535, and TA1537 and Escherichia coli tester strain WP2uvrA were exposed to ethoxyquin at concentrations of 10.0, 33.3, 100, 333, 1,000, 2,000, and 5,000 µg/plate resp. 33.3, 100, 333, 1,000, 3,330 and 5,000 µg/plate in the presence and absence of mammalian metabolic activation (Aroclor-induced rat liver S9).
Ethoxyquin was tested up to the limit concentration 5000 µg/plate. The positive controls induced the appropriate responses in the corresponding strains.There was no evidence or a concentration related positive response of induced mutant colonies over background.
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