Registration Dossier

Administrative data

Endpoint:
basic toxicokinetics
Adequacy of study:
other information
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
Precursors of carcinogenic hydrocarbons in tobacco smoke.
Author:
Gil-Av E and Shabtai J
Year:
1963
Bibliographic source:
Nature 197, 1065-1066. |cited in: Patty's 4th Edition, Volume II, Part B, page 1284.

Materials and methods

Objective of study:
metabolism

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Applicant's summary and conclusion

Conclusions:
1,5-Cyclooctadiene is metabolized in rabbits and rats to dihydroxycyclooctyl mercapturic acid and to sulfate and glucuronide conjugates.