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EC number: 203-907-1 | CAS number: 111-78-4
RESULTS OF PILOT STUDY: 100 % test substance caused no dermal irritation RESULTS OF TEST - Sensitization reaction: 0/20 animals positive at 24 hours and at 48 hours = no sensitization no animals positive in control group no skin reaction upon corn oil treatment on opposite side (both groups)
- Clinical signs: 1st induction, FCA application sites (all): severe erythema, edema, and
necrosis 1st induction, test substance application sites: distinct erythema and edema 1st induction, vehicle application sites: slight erythema and edema 2nd induction, test and control groups: 1 hour after patch removal: erythema over the entire application area,
severe and partly bleeding inflammation with edema (wounds), partly eschar
formation, slight inflammation of the other injection sites, agitation of
the animals and scratching in the application area. 24 hours after patch removal: formation of eschar on inflamed injection
areas. - Other: Mean body weight gain 128 g in test group, 116 g in control
group = expected range.
In a guinea pig maximization test according to OECD 406 performed with the test item 1,5 -cyclooctadiene, after intracutane and epidermal inductions and 24 hours as well as 48 hours after epidermal challenge, no one of the 20 animals examined in this study showed positive response regarding dermal sensitization.
Under the conditions of this guinea pig maximization test, the test item 1,5 -cyclooctadien showed no dermal sensitization in male guinea pigs.
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