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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
15-Sep-2014 to 20-Sep-2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
GLP compliance:
yes (incl. certificate)
Remarks:
Staatliches Gewerbeaufsichtsamt Hildeshelm
Type of method:
flask method
Key result
Water solubility:
1.6 g/L
Conc. based on:
test mat.
Temp.:
20 °C
pH:
6.1

Results

Water Solubility Results at 20 °C

Preincubation period

Replication No.

Results for test item (g/L)

Concentration1)

Mean

24 h

1

1.57

1.56

2

1.56

48 h

1

1.58

1.60

2

1.63

72 h

1

1.64

1.65

2

1.66

Mean (24 – 72 h)

1.60

Deviation (%)

5

 

1) mean value of two injections, sum of two isomer signals

 

Isomer distribution

The mean isomer distribution changed from 46 % of isomer 1 and 54 % of isomer 2 in the external standard samples to 69.9 % of isomer 1 and 30.1 % of isomer 2 in the solubility samples, indicating a higher water solubility of isomer 1.

 

Isomer distribution for the test item in the test samples

Preincubation time

Replicate No.

Isomer 1

Isomer 2

(Area %)

24 h

1

70.3

29.7

2

69.9

30.1

48 h

1

69.5

30.5

2

69.0

31.0

72 h

1

70.1

29.9

2

70.3

29.7

Mean value

69.9

30.1

SD

0.5

0.5

CV

1

2

 SD = Standard deviation

CV = Coefficient of variation

Isomer distribution for the test item in the external standard samples

Calibration standard

Isomer 1

Isomer 2

(Area %)

1 mg/L

48

52

2.5 mg/L

591)

411)

5 mg/L

46

54

10 mg/L

45

55

25 mg/L

46

54

35 mg/L

46

54

50 mg/L

47

53

Mean value

46

54

SD

1

1

CV

2

2

 SD = Standard deviation

CV = Coefficient of variation

1) Determined to be an outlier via Grubbs-test, not taken into account.

Summary

The solubility of the test item was determined to be 1.60 g/L (pH 6.1) at 20 +0.5 °C.

Conclusions:
A water solubility value of 1.6 g/L (at 20 °C, pH 6.1) was determined for the test substance according to OECD 105 (1995).

Description of key information

Water solubility: 1.6 g/L at 20 °C, pH = 6.1 (flask method)

Key value for chemical safety assessment

Water solubility:
1.6 g/L
at the temperature of:
20 °C

Additional information

A water solubility value of 1.6 g/L (at 20 °C, pH 6.1) was determined for the test substance using flask method according to OECD 105 (1995).