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EC number: 604-351-6 | CAS number: 143390-89-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to terrestrial arthropods
Administrative data
- Endpoint:
- toxicity to terrestrial arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 213 (Honeybees, Acute Oral Toxicity Test)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 214 (Honeybees, Acute Contact Toxicity Test)
- GLP compliance:
- yes
- Application method:
- other: contact and oral
Test material
- Reference substance name:
- methyl (2E)-2-methoxyimino-2-[2-[(2-methylphenoxy)methyl]phenyl]acetate
- EC Number:
- 604-351-6
- Cas Number:
- 143390-89-0
- Molecular formula:
- C18 H19 N O4
- IUPAC Name:
- methyl (2E)-2-methoxyimino-2-[2-[(2-methylphenoxy)methyl]phenyl]acetate
- Details on test material:
- - Name of test material (as cited in study report): BAS 490 F
- Physical state: light brown solid
- Analytical purity: 97.8% ± 1.0% active ingredient
- Batch No.: COD-000225
- Storage condition of test material: at room temperature
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test substrate
- Vehicle:
- yes
Test organisms
- Test organisms (species):
- Apis mellifera
- Animal group:
- Hymenoptera (honeybees)
- Details on test organisms:
- TEST ORGANISM
- Common name: worker honey bees
- Source: Honey bee colonies, disease-free and queen-right, bred by IBACON GmbH, Darmstadt, Germany
- Age at test initiation: adult
- Sex: female
- Cultural background:
- Disease free: yes
- Kept according to standard practices: yes
Study design
- Study type:
- laboratory study
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 25 - 26 °C
- Humidity:
- 37-70%
- Photoperiod and lighting:
- Darkness (expect during observation)
- Details on test conditions:
- TEST SYSTEM
Type: stainless steel cages
Size: 10 x 8.5 x 5.5. cm (length x width x height)
No. of individuals/unit: 10
Replicates: 5 per test item dose, controls and reference item dose
Food: Commercial ready-to-use syrup (Apiinvert; 30 % Saccharose, 31 % Glucose, 39 % Fructose) ad libitum; was given directly after treatment using syringes; no replacements of the food was necessary during the experimental time of the experiments (48 h)
TEST PARAMETERS: mortality, behavioural abnormalities after 4, 24, 48 hours - Nominal and measured concentrations:
- Nominal dose level of the test item in the contact test and the oral test: 100 µg a.i./bee
Measured dose level of the test item in the oral test: 111.0 µg a.i./bee
Nominal dose level of the reference item in the contact test: 0.3, 0.2, 0.15, 0.1 µg dimethoate per bee
Nominal dose level of the reference item in the oral test: 0.3, 0.15, 0.08, 0.05 µg dimethoate per bee
Measured dose level of the reference item in the oral test: 0.28, 0.15, 0.08, 0.05 µg dimethoate per bee - Reference substance (positive control):
- yes
- Remarks:
- dimethoate 400 mg/L (nominal)
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- LD50
- Effect conc.:
- > 100 µg per animal
- Nominal / measured:
- nominal
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Remarks on result:
- other: contact test
- Duration:
- 48 h
- Dose descriptor:
- LD50
- Effect conc.:
- > 111 µg per animal
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Remarks on result:
- other: oral test
- Details on results:
- CONTACT TOCICITY
- Mortality in the water control: none
- Mortality in the solvent control: none
- Behavioural abnormalities: none
ORAL TOCICITY
- Mortality in the water control: none
- Mortality in the solvent control: none
- Behavioural abnormalities: none - Results with reference substance (positive control):
- Contact LD50 (48 h) = 0.19 µg/bee
Oral LD50 (48 h) = 0.15 µg/bee
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.