Registration Dossier
Registration Dossier
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EC number: 405-800-7 | CAS number: 27955-94-8
Endpoint summary
Administrative data
Description of key information
There are two studies available for the oral and dermal acute toxicty of the test substance. The corresponding LD50 were determined as: LD50 (rat) oral >5000 mg/Kg bw. LD50 (rat) dermal >2000 mg/Kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
In two separate studies the acute oral and acute dermal toxicity LD50 was determined.
For oral: the test substance suspended in 1% aqueous methylcellulose applied as a single oral dose 5000 mg/kg. The rats were observed for 14 days for mortality and clinical signs. There were no deaths during the observation period and gross necropsy findings were normal. The acute oral LD50 (rat) was >5000 mg/kg bw.
For dermal: The test substance suspended in water was applied with an occlusive dressing at single dose 2000 mg/kg, removed after 24 hours with observation for 14 days. There were no deaths or other clinical signs of toxicity during the observation period. The acute dermal LD50 (rat) was >2000 mg/kg bw.
Justification for classification or non-classification
The substance does not meet classification criteria under EU Directive 67/548/EEC for acute oral toxicity.
The substance does not meet classification criteria under Regulation (EC) No 1272/2008 for acute toxicity.
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