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EC number: 308-208-6 | CAS number: 97925-95-6
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term studies from all three trophic levels (algae, daphnia, fish) are available for Atmer 163 (CAS No. 97925-95-6). Aquatic algae was found to be the most sensitive aquatic species with an EC50 (72 h) of 0.0087 mg/L. Short-term studies with freshwater fish obtained a LC50 (96 h) of 0.355 mg/L. An EC50 (48 h) of 0.59 mg/L resulted in toxicity testing with the freshwater invertebrateDaphnia magna. Toxic effects to activated sludge microorganisms were observed as well (EC50 (3 h) of 27 mg/L). Valid studies on the long-term toxicity to aquatic algae and invertebrates are available. Testing with aquatic algae resulted in a NOEC (72 h) of 0.0044 mg/L based on growth rate, whereas chronic testing with D. magna resulted in a NOEC (21 d) of 0.1 mg/L based on mortality. An inhibition of reproduction of D. magna was not observed at all concentrations tested. No further long-term testing with fish was deemed necessary. It is expected that the most sensitive species (aquatic algae) was tested adequately. It is not expected that long-term testing with fish would result in lower effect concentrations. This evidence is based on (Q)SAR calculations using ECOSAR v1.00 for the C13 and C15 compounds of Atmer 163. The estimated long-term value is 0.012 - 0.039 mg/L towards freshwater fish and 0.018 - 0.02 mg/L for aquatic invertebrates. Both results are in the same order of magnitude which is also the case for the available experimental acute data (LC50 (96 h) of 0.355 mg/L (Oncorhynchus mykiss) and EC50 (48 h) of 0.59 mg/L for D. magna). The available chronic study with D. magna did not result in much lower effect concentrations (NOEC (21 d): 0.1 mg/L). Moreover, the substance has a low potential for bioaccumulation limiting the possibility of chronic effects.
In conclusion Atmer 163 was found to provoke very toxic effects, in both acute and chronic aquatic ecotoxicity tests with algae beeing the most sensitive species. In addition, hazardous effects on sewage treatment plant microorganisms are anticipated as well, as low effect concentrations for respiration inhibition were determined in a short term respiration inhibition test.
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