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Ecotoxicological information

Long-term toxicity to fish

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Endpoint:
fish early-life stage toxicity
Data waiving:
other justification
Justification for data waiving:
other:
Analytical monitoring:
yes
Endpoint:
long-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Accepted calculation method
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6
GLP compliance:
no
Remarks:
calculation
Test organisms (species):
other: freshwater fish
Test type:
other: calculation
Total exposure duration:
28 d
Duration:
28 d
Dose descriptor:
other: geometric mean of LOEC and NOEC
Effect conc.:
0.039 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: Atmer 163 (C13): based on calculation
Duration:
28 d
Dose descriptor:
other: geometric mean of NOEC and LOEC
Effect conc.:
0.012 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: Atmer 163 (C15): based on calculation

ECOSAR program (v1.00) Results:

=====================================================

Atmer 163 (C13)

SMILES : CCCCCCCCCCCCCN(CCO)(CCO)

MOL FOR: C17 H37 N1 O2

MOL WT : 287.49

Log Kow: 4.39 (KowWin estimate)

Wat Sol: 81 mg/L (measured)

ECOSAR v1.00 Class(es) Found

------------------------------

Aliphatic Amines

Predicted

ECOSAR Class Organism Duration End Pt mg/L (ppm)

=========================== ================== ======== ====== ==========

Aliphatic Amines : Fish 96-hr LC50 1.841

Aliphatic Amines : Daphnid 48-hr LC50 0.304

Aliphatic Amines : Green Algae 96-hr EC50 0.284

Aliphatic Amines : Fish ChV 0.039

Aliphatic Amines : Daphnid ChV 0.020

Aliphatic Amines : Green Algae ChV 0.060

Aliphatic Amines : Fish (SW) 96-hr LC50 2.005

Aliphatic Amines : Mysid Shrimp (SW) 96-hr LC50 0.273

Aliphatic Amines : Green Algae (SW) 96-hr EC50 0.276

Aliphatic Amines : Fish (SW) ChV 0.039

Aliphatic Amines : Mysid Shrimp (SW) ChV 0.020

Aliphatic Amines : Green Algae (SW) ChV 0.061

=========================== ================== ======== ====== ==========

Neutral Organic SAR : Fish 96-hr LC50 2.100

(Baseline Toxicity) : Daphnid 48-hr LC50 1.618

: Green Algae 96-hr EC50 1.860

: Fish ChV 0.189

: Daphnid ChV 0.228

: Green Algae ChV 1.042

Note: * = asterisk designates: Chemical may not be soluble

enough to measure this predicted effect.

Aliphatic Amines:

----------------

For Fish 96-hr LC50: For aliphatic amines with log Kow greater than 7.0,

a test duration of greater than 96 hrs may be required for proper

expression of toxicity. Also, if the toxicity value obtained by the use

of this equation exceeds the water solubility (measured or estimated),

mortalities greater than 50% would not be expected in a saturated

solution during an exposure period of 96 hrs.

For Daphnid 48-hr LC50: For aliphatic amines with log Kow greater than

5.0, a test duration of greater than 48 hrs may be required for proper

expression of toxicity. Also, if the toxicity value obtained by the use

of this equation exceeds the water solubility (measured or estimated),

significant mortalities would not be expected in a saturated solution

during an exposure period of 48 hrs.

For Green Algae Acute Toxicity Values: If the log Kow of the chemical is

greater than 7, or if the compound is solid and the EC50 exceeds the water

solubility by 10X, no effects at saturation are predicted for these endpoints.

For Mysid Shrimp Acute Toxicity Values: If the log Kow of the chemical is

greater than 6, or if the compound is solid and the EC50 exceeds the water

solubility by 10X, no effects at saturation are predicted for these endpoints.

For Fish and Daphnid Chronic Toxicity Values: If the log Kow of the chemical

is greater than 8.0, or if the compound is solid and the ChV exceeds the water

solubility by 10X, no effects at saturation are predicted for these endpoints.

For Green Algae Chronic Toxicity Values: If the log Kow of the chemical

is greater than 7.0, or if the compound is solid and the ChV exceeds the water

solubility by 10X, no effects at saturation are predicted for these endpoints.

ECOSAR v1.00 SAR Limitations:

----------------------------

Maximum LogKow: 6.0 (Fish, Mysid LC50)

Maximum LogKow: 5.0 (Daphnid LC50)

Maximum LogKow: 7.0 (Green Algae EC50)

Maximum LogKow: 8.0 (Fish, Daphnid ChV)

Maximum LogKow: 7.0 (Green Algae ChV)

Maximum Mol Wt: 1000

Baseline Toxicity SAR Limitations:

---------------------------------

Maximum LogKow: 5.0 (Fish 96-hr LC50; Daphnid LC50)

Maximum LogKow: 6.4 (Green Algae EC50)

Maximum LogKow: 8.0 (ChV)

Maximum Mol Wt: 1000

===========================================================

Atmer 163 (C15)

SMILES : CCCCCCCCCCCCCCCN(CCO)(CCO)

MOL FOR: C19 H41 N1 O2

MOL WT : 315.54

Log Kow: 5.37 (KowWin estimate)

Wat Sol: 81 mg/L (measured)

ECOSAR v1.00 Class(es) Found

------------------------------

Aliphatic Amines

Predicted

ECOSAR Class Organism Duration End Pt mg/L (ppm)

=========================== ================== ======== ====== ==========

Aliphatic Amines : Fish 96-hr LC50 0.518

Aliphatic Amines : Daphnid 48-hr LC50 0.105

Aliphatic Amines : Green Algae 96-hr EC50 0.135

Aliphatic Amines : Fish ChV 0.012

Aliphatic Amines : Daphnid ChV 0.018

Aliphatic Amines : Green Algae ChV 0.022

Aliphatic Amines : Fish (SW) 96-hr LC50 0.569

Aliphatic Amines : Mysid Shrimp (SW) 96-hr LC50 0.092

Aliphatic Amines : Green Algae (SW) 96-hr EC50 0.130

Aliphatic Amines : Fish (SW) ChV 0.012

Aliphatic Amines : Mysid Shrimp (SW) ChV 0.018

Aliphatic Amines : Green Algae (SW) ChV 0.023

=========================== ================== ======== ====== ==========

Neutral Organic SAR : Fish 96-hr LC50 0.340

(Baseline Toxicity) : Daphnid 48-hr LC50 0.295

: Green Algae 96-hr EC50 0.508

: Fish ChV 0.030

: Daphnid ChV 0.049

: Green Algae ChV 0.340

Note: * = asterisk designates: Chemical may not be soluble

enough to measure this predicted effect.

Aliphatic Amines:

----------------

For Fish 96-hr LC50: For aliphatic amines with log Kow greater than 7.0,

a test duration of greater than 96 hrs may be required for proper

expression of toxicity. Also, if the toxicity value obtained by the use

of this equation exceeds the water solubility (measured or estimated),

mortalities greater than 50% would not be expected in a saturated

solution during an exposure period of 96 hrs.

For Daphnid 48-hr LC50: For aliphatic amines with log Kow greater than

5.0, a test duration of greater than 48 hrs may be required for proper

expression of toxicity. Also, if the toxicity value obtained by the use

of this equation exceeds the water solubility (measured or estimated),

significant mortalities would not be expected in a saturated solution

during an exposure period of 48 hrs.

For Green Algae Acute Toxicity Values: If the log Kow of the chemical is

greater than 7, or if the compound is solid and the EC50 exceeds the water

solubility by 10X, no effects at saturation are predicted for these endpoints.

For Mysid Shrimp Acute Toxicity Values: If the log Kow of the chemical is

greater than 6, or if the compound is solid and the EC50 exceeds the water

solubility by 10X, no effects at saturation are predicted for these endpoints.

For Fish and Daphnid Chronic Toxicity Values: If the log Kow of the chemical

is greater than 8.0, or if the compound is solid and the ChV exceeds the water

solubility by 10X, no effects at saturation are predicted for these endpoints.

For Green Algae Chronic Toxicity Values: If the log Kow of the chemical

is greater than 7.0, or if the compound is solid and the ChV exceeds the water

solubility by 10X, no effects at saturation are predicted for these endpoints.

ECOSAR v1.00 SAR Limitations:

----------------------------

Maximum LogKow: 6.0 (Fish, Mysid LC50)

Maximum LogKow: 5.0 (Daphnid LC50)

Maximum LogKow: 7.0 (Green Algae EC50)

Maximum LogKow: 8.0 (Fish, Daphnid ChV)

Maximum LogKow: 7.0 (Green Algae ChV)

Maximum Mol Wt: 1000

Baseline Toxicity SAR Limitations:

---------------------------------

Maximum LogKow: 5.0 (Fish 96-hr LC50; Daphnid LC50)

Maximum LogKow: 6.4 (Green Algae EC50)

Maximum LogKow: 8.0 (ChV)

Maximum Mol Wt: 1000

Description of key information

The Chemical Safety Assessment according to Annex I of Regulation (EC) No 1907/2006 does not indicate the need to investigate further the chronic toxicity of Atmer 163 to fish.

Key value for chemical safety assessment

Additional information