Registration Dossier
Registration Dossier
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EC number: 235-008-5 | CAS number: 12054-48-7
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Peer reviewed data, acceptable for assessment.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Genotoxic activity and potency of 135 compounds in the Ames reversion test and in a bacterial DNA-repair test.
- Author:
- De Flora S. et al.
- Year:
- 1 984
- Bibliographic source:
- OECD SIDS-Draft; original source: Mutat. Res., 133, 161-198
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- nickel nitrate
- IUPAC Name:
- nickel nitrate
- Details on test material:
- - Name of test material (as cited in study report): nickel nitrate
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: Salmonella typhimurium TA1535, TA100, TA1538, TA98, TA1537, TA97
- Metabolic activation:
- with and without
- Test concentrations with justification for top dose:
- no data
Controls
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- not specified
- True negative controls:
- not specified
- Positive controls:
- not specified
- Positive control substance:
- not specified
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: TA1535, TA100, TA1538, TA98, TA1537, TA97
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Negative results were seen in the bacterial reverse mutation assay.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
