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Ecotoxicological information

Long-term toxicity to fish

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Description of key information

Urea is of inherently low toxicity to fish species: it is a normal product of protein catabolism and therefore fish have evolved effective excretion mechanisms.  Additionally, exposure will be limited by the action of microorganisms and incorporation of urea into the urea cycle.

Key value for chemical safety assessment

Additional information

No scientifically validated data are available, but a study with mosquitofish caught in the wild showed no adverse effects after exposure for 1 week to environmental relevant concentrations. Therefore a waiver is proposed for this endpoint. Urea is of inherently low toxicity to fish species: it is a normal product of protein catabolism and therefore fish have evolved effective excretion mechanisms. Additionally, exposure will be limited by the action of microorganisms and incorporation of urea into the nitrogen cycle.