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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Published study: non-standard species

Data source

Reference
Reference Type:
publication
Title:
Effect of an expansion-processed mixture of grain and urea on rumen metabolism in cattle and on urea toxicity
Author:
Stiles, D.A., Bartley, E.E., Meyer, R.M., Deyoe, C.W. & Pfost, H.B.
Year:
1970
Bibliographic source:
J. Dairy Science 53(10): 1436-1447

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Investigation of the effects of diet on urea toxicity in cows
GLP compliance:
no
Remarks:
: older published study
Test type:
other:
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
No information available

Test animals

Species:
cattle
Strain:
other: Holstein & Shorthorn
Sex:
male/female
Details on test animals and environmental conditions:
No information available; cow could refer to female animals?

Administration / exposure

Route of administration:
other: oral (diet)
Vehicle:
other: in feed
Details on oral exposure:
No information available
Doses:
Animals were fed quantities of grain containing 20% urea at dose levels equivalent to 26-118 g/100 kg bw (260-1180 mg/kg bw).
No. of animals per sex per dose:
Two
Control animals:
not specified
Details on study design:
No information available
Statistics:
No information available

Results and discussion

Preliminary study:
No information available
Effect levels
Sex:
male/female
Dose descriptor:
LDLo
Effect level:
600 mg/kg bw
Mortality:
No information available
Clinical signs:
No information available
Body weight:
No information available
Gross pathology:
No information available
Other findings:
No information available

Any other information on results incl. tables

Deaths occurred in animals administered urea at dose levels equivalent to 600 and 1080 mg/kg bw. Adaptation was demonstrated as lower toxicity seen in animals previously administered urea.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information non-relevant species Criteria used for interpretation of results: EU
Conclusions:
Deaths occurred in animals administered urea at dose levels equivalent to 600 and 1080 mg/kg bw.
Executive summary:

The authors investigated the toxicity of urea in cattle. Deaths occurred in animals administered urea at dose levels equivalent to 600 and 1080 mg/kg bw. Adaptation was demonstrated as lower toxicity seen in animals previously administered urea.