Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
200-315-5
CAS no.:
57-13-6
Index number:
Molecular formula:
CH4N2O
SMILES:
NC(N)=O
InChI:
InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4)
Type of substance:
Mono constituent substance
Origin:
Organic
Registered compositions:
39
Of which contain:
6 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

According to the notifications provided by companies to ECHA in REACH registrations no hazards have been classified.
According to the majority of notifications provided by companies to ECHA in CLP notifications no hazards have been classified.

Breakdown of all 5918 C&L notifications submitted to ECHA

Not Classified
Eye Irrit. 2 H319
Skin Irrit. 2 H315
Carc. 2 H351
STOT SE 2 H371
STOT SE 3 H335
Aquatic Chronic 4 H413
Acute Tox. 4 H302
Acute Tox. 4 H312
Acute Tox. 4 H332
Skin Sens. 1 H317
Resp. Sens. 1 H334
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification.

Properties of concern

  • Ss
  • Sr

Regulatory activities

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 210 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Registration dossiers submitted to ECHA for this substance have been evaluated under REACH.
Substance Evaluation:
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Classification Labelling & Packaging (CLP)

Harmonised C&L:
Notification:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is manufactured and/or imported in the European Economic Area in 10 000 000 - 100 000 000 tonnes per year.

This substance is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

This substance is used in the following products: fertilisers, cosmetics and personal care products and pH regulators and water treatment products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

Release to the environment of this substance can occur from industrial use: formulation of mixtures. Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following activities or processes at workplace: the low energy manipulation of substances bound in materials or articles and high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding).

Release to the environment of this substance can occur from industrial use: formulation of mixtures, in processing aids at industrial sites and in the production of articles. Other release to the environment of this substance is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), indoor use as processing aid, outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints).

This substance can be found in products with material based on: fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys), paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper), leather (e.g. gloves, shoes, purses, furniture), paper used for packaging (excluding food packaging) and wood (e.g. floors, furniture, toys).

This substance is used in the following products: fertilisers, pH regulators and water treatment products and laboratory chemicals. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: agriculture, forestry and fishing, formulation of mixtures and/or re-packaging and municipal supply (e.g. electricity, steam, gas, water) and sewage treatment. This substance is used for the manufacture of: chemicals.

This substance is used in the following activities or processes at workplace: transfer of chemicals, non-industrial spraying, mixing in open batch processes, transfer of substance into small containers, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, hand mixing with intimate contact only with personal protective equipment available and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: formulation of mixtures. Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

This substance is used in the following products: fertilisers, pH regulators and water treatment products, polymers and plant protection products. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following activities or processes at workplace: transfer of chemicals, mixing in open batch processes, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, transfer of substance into small containers, closed processes with no likelihood of exposure and batch processing in synthesis or formulation with opportunity for exposure.

Release to the environment of this substance can occur from industrial use: formulation of mixtures, as an intermediate step in further manufacturing of another substance (use of intermediates), manufacturing of the substance, in the production of articles, formulation in materials, in processing aids at industrial sites, as processing aid and of substances in closed systems with minimal release. Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following products: pH regulators and water treatment products, laboratory chemicals, fertilisers, polymers and textile treatment products and dyes. This substance has an industrial use resulting in manufacture of another substance (use of intermediates).

This substance is used in the following areas: formulation of mixtures and/or re-packaging, municipal supply (e.g. electricity, steam, gas, water) and sewage treatment and mining. This substance is used for the manufacture of: chemicals, pulp, paper and paper products, textile, leather or fur and mineral products (e.g. plasters, cement).

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, mixing in open batch processes, batch processing in synthesis or formulation with opportunity for exposure, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: as processing aid, in processing aids at industrial sites, in the production of articles, formulation of mixtures, as an intermediate step in further manufacturing of another substance (use of intermediates) and manufacturing of the substance. Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

This substance is used in the following activities or processes at workplace: transfer of chemicals, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation, closed processes with no likelihood of exposure, transfer of substance into small containers, mixing in open batch processes, batch processing in synthesis or formulation with opportunity for exposure and laboratory work.

Release to the environment of this substance can occur from industrial use: manufacturing of the substance, as an intermediate step in further manufacturing of another substance (use of intermediates), formulation of mixtures, of substances in closed systems with minimal release, as processing aid and for thermoplastic manufacture.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • 151 Products ltd, The Old School House 39 Bengal Street M4 6AF Manchester Lancashire United Kingdom
  • 3M Belgium BVBA/SPRL, Hermeslaan 7 1831 Diegem Belgium
  • A&C Chemicals Europe Ltd. , Questum, Cahir Road Ballingarrane E91 V239 Clonmel Co. Tipperary Ireland
  • AB Achema, Jonalaukio km. Ruklos sen. LT55550 Jonavos r. Lithuania
  • Acros Organics bvba, Janssen Pharmaceuticalaan 3a B-2440 Geel Belgium
  • AGRA GROUP a.s., Tovarni 201 387 15 Strelske Hostice Czech Republic Czech Republic
  • Agrium Egypt SA, Avenue Louise 326 box 36 1050 Brussels Belgium
  • Agroplasma SL, Calle Torre del Mar 56 29006 Málaga Spain
  • Agropolychim JSC, Industrial zone 9160 Devnya Varna Bulgaria
  • ALMAMET GmbH, Gewerbestraße 5a 83404 Ainring Germany
  • Alpha Osta, Birztalu Street 26 LV 1015 Riga Latvia Latvia
  • Ameropa Düngemittel GmbH, Ferdinandstraße 55-57 20095 Hamburg Germany
  • Amurco SRL Bacau, Chimiei nr.1 600289 Bacau Romania
  • Arcerion GmbH, Gabrielenstr. 15 80636 München Germany
  • Archroma Germany GmbH, Kasteler Str. 45 65203 Wiesbaden Germany
  • ARCHROMA IBÉRICA, S.L., ZAL-Prat c/Cal Coracero, 46-56 08820 El Prat de Llobregat Spain
  • Arysta LifeScience Germany GmbH, Elisabethstr. 44-46 40217 Duesseldorf Germany Germany
  • AS DBT, Narva mnt 7 D 10117 Tallinn Estonia
  • Asahi Chemical Europe s,r,o,, Lužná 591/4 16000 Praha 6 - Vokovice Praha Czech Republic
  • Ashland Services BV (0311), Noordweg 9 3336 LH Zwijndrecht Netherlands
  • Avantor Performance Materials Poland S.A., Sowińskiego 11 44-100 Gliwice Poland
  • AVESTRA CHEMICAL SERVICES OY, ORs, Uotilantie 35 01860 Perttula Finland
  • Azotal S.p.A., Viale Papa Giovanni XXIII, 94/D 24121 Bergamo Lombardia Italy
  • B-Lands Consulting (811251-8), World Trade Center 5 Place Robert Schuman - BP 1510 38025 Grenoble France France
  • B-Lands Consulting (811323-8), World Trade Center, 5 Place Robert Schuman - BP 1510 38025 Grenoble France France
  • BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany
  • Bayer AG, Kaiser-Wilhelm-Allee 51373 Leverkusen Germany
  • Belor Eurofert GmbH, Mainstrasse, 5 96052 Bamberg Germany
  • BENS consulting d.o.o., Bakovniška 7 1241 Kamnik Slovenia
  • BENS consulting d.o.o. (OR HIP Azotara), Bakovniška 7 1240 Kamnik Slovenia
  • Biofert Ltd, Constantinou Paparigopoulu P.O. Box 58363 3733 Limassol Cyprus
  • BNH-OIL Polska Sp. z o.o., ul.Tadeusza Rejtana 17, lok 14 02-516 Warszawa Poland
  • Borealis Agrolinz Melamine GmbH, St. Peter-Str. 25 4021 Linz Austria
  • Brenntag Nordic OY, Äyritie 16 01510 Vantaa Finland
  • Brockley Group Limited, Unit 3 Block 5.1. Woodford Business Park D17CY84 Santry Co Dublin Ireland
  • BYK-Netherlands B.V., Danzigweg 23 7418 EN Deventer Netherlands
  • Cambridge Environmental Assessments, part of RSK ADAS Europe (Ireland) Ltd. (OJI), Office Suite B, Bluebell Business Centre, Old Naas Road D12 XV7K Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 D02 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED, Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Chemical Inspection & Regulation Service Limited (Beijing Leili Marine Bioindustry Inc.), Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • CHEMICAL INSPECTION & REGULATION SERVICE LIMITED(Kingenta Ecological Engineering Group Co., Ltd), Room 002, Regus Harcourt Centre D02 HW77 Dublin Ireland
  • Chemreach GmbH, Akazienweg 30 48317 Drensteinfurt Germany
  • Chimica Pomponesco Spa, Via delle Industrie, 1 46030 Pomponesco Lombardia Italy
  • Clariant Plastics & Coatings (Deutschland) GmbH, Brüningstrasse 50 65929 Frankfurt am Main Germany
  • Consorzio Sostanze Chimiche Fertilizzanti e Reach, Via delle Acque, 43 48124 Ravenna RA Italy
  • CR Capital Resources Limited, 1 Aspen Court, Old Bray Road 0 Cornelscourt Dublin 18 Ireland
  • Croda EU B.V. (OR1), Buurtje 1 2802 BE Gouda Netherlands
  • CS Regulatory Ltd 1L-15, The Old Courthouse St Peters Churchyard DE11NN Derby Derbyshire United Kingdom
  • DEKRA Assurance Services GmbH OR07, Handwerkstr. 15 70565 Stuttgart Germany
  • DKSH GmbH, Baumwall 3 20459 Hamburg Germany
  • DniproAZOT Trade, Stochovska 50/821 16100 Praha Czech Republic
  • Dunamobil Kft., Lencse u. 8. H-6300 Kalocsa Bács-Kiskun Hungary
  • DUSLO, Administrativna budova ev.č 1236 927 03 Šaľa Slovakia
  • DyStar Colours Distribution GmbH, Am Prime-Parc 12 65479 Raunheim Germany
  • Ecolab Production Belgium B.V.B.A., Havenlaan 4 3980 Tessenderlo Belgium
  • Envigo CRS SAU 024, Centro Industrial Santiga - Carrer Argenters, 6 08130 Santa Perpetua de Mogoda Barcelona Spain
  • Ercros SA, Avenida Diagonal 593-595 08014 Barcelona Spain
  • EuroChem Agro GmbH, Reichskanzler-Müller-Staße 23 68165 Mannheim Baden-Württemberg Germany
  • EVERGREEN GARDEN CARE UK LTD, 1 Archipelago Lyon Way GU167ER Frimley Camberley United Kingdom
  • Everlight Europe B.V., Rivium Boulevard 112b 2909LK Capelle a/d Ijssel Netherlands
  • Everris International BV, Nijverheidsweg 1-5 6422 PD Heerlen Netherlands
  • Fertiberia, S.A., Paseo de la Castellana 259 D -Planta 48 28046 Madrid Spain
  • FERTINAGRO BIOTECH, S.L., Polig. Ind. La Paz,185 44195 Teruel Spain
  • Finish Metal Plating, S.L., Poligono industrial el Pl.; Calle Miquel Torelló i Pagés, 42 08750 Molins de Rei Barcelona Spain
  • FUJIFILM Europe BV, Oudenstaart 1 5047 TK Tilburg Netherlands
  • Fujifilm Imaging Colorants Newcastle, 6th Floor, Acresfield 8-10 Exchange Street M2 7HA Manchester Manchester United Kingdom
  • Gleadell Agriculture Ltd, Lindsay House Hemswell Cliff DN21 5TH Gainsborough Lincolnshire United Kingdom
  • Grupa Azoty Zaklady Chemiczne "POLICE" Spolka Akcyjna, Kuznicka 1 72-010 Police Poland
  • Grupa Azoty Zakłady Azotowe Kędzierzyn Spółka Akcyjna, skr. poczt. 163 ul. Mostowa 30A 47-220 Kędzierzyn-Kożle Poland
  • Grupa Azoty Zakłady Azotowe „Puławy” S.A., al. Tysiąclecia Państwa Polskiego 13 24-110 Puławy Poland
  • Haifa North West Europe BVBA-SO, Generaal de Wittelaan 17, bus 16 B-2800 Mechelen Belgium
  • Heliopotasse SA, 25 place de la réunion 68100 Mulhouse France
  • Helm AG, Nordkanalstraße 28 20097 Hamburg Germany
  • HH Compliance Ltd , Rubicon Centre C.I.T. Campus T12 Y275 Bishopstown Cork Ireland
  • Huntsman Textile Effects (Germany) GmbH, Rehlinger Str. 1 D-86462 Langweid a.Lech Germany
  • INDUSTRIA QUIMICA RIO BLANCO, SL , Lg. Abanqueiro 15938 Boiro A Coruña Spain
  • International Cosmetics and Chemical Services Ltd 324, 26 Pembroke Street Upper Suite 10016 D02 X361 Dublin 2 Ireland
  • INTERTEC srl, Via Nazionale, 3 52011 BIBBIENA (AR) Italy
  • Intertek Deutschland GmbH 14, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • Intertek Deutschland GmbH 41, Stangenstrasse 1 70771 Leinfelden-Echterdingen Germany
  • INTERTEK FRANCE, Ecoparc 2 27400 HEUDEBOUVILLE France
  • JSC "Arvi fertis", P. Armino St. 65 LT–68127 Marijampole Lithuania
  • Kastamonu Bulgaria AD, Shipchenska epopeya 24 Shipchenska epopeya 24 6151 Gorno Sahrane Stara Zagora Bulgaria
  • Kemira Oyj, Energiakatu 4 P.O.Box 330 FI-00101 HELSINKI Finland
  • Kemira Oyj , Porkkalankatu 3 P.O.Box 330 FI-00101 Helsinki Finland
  • KEYTRADE IBERIA, S.L., calle Villalar, 4, 1ero derecha 28001 Madrid Spain
  • KIST Europe Forschungsgesellschaft mbH_14, Universitaet des Saarlandes Campus E 71 D-66123 Saarbruecken Germany
  • KREX Sp. z o.o., Kleszczelowska 84A 17-100 Bielsk Podlaski Poland
  • Kronospan Sebes SA, Mihail Kogalniceanu Nr 59 515800 Sebes jud.Alba Romania Romania
  • Lamberti Iberia s.a.u., Calle Ceuta 1 - Poligon industrial El Colomer 12200 Onda Castellon Spain
  • Lamberti S.p.A., via Piave 18 21041 Albizzate Varese Italy
  • Lanxess Deutschland GmbH, Kennedyplatz 1 50569 Köln Germany
  • Lifosa-2, Juodkiskio 50 LT-57502 Kedainiai Lithuania
  • Lifosa-4, Juodkiskio 50 LT-57502 Kedainiai Lithuania
  • Metadynea Austria GmbH, Hafenstrasse 77 A-3500 Krems Austria
  • Muntajat B.V, 19th Floor, Tower E, WTC The Hague Prinses Margrietplantsoen 78-A 2595 The Hague Netherlands
  • Nalco Europe B.V., Oude Rhijnhofweg 17 2342 BB Oegstgeest Netherlands
  • Nalco Limited, P.O. Box 11, Winnington Avenue, CW8 4DX Northwich, Cheshire United Kingdom
  • NAM & NAM Europe GmbH, Emil-Figge-Str. 80 44227 Dortmund(090) Germany
  • Nitrofert AS, Estonia, Jarvekula tee 1 30197 Kohtla-Jarve Estonia
  • Nitrogénművek Zrt., Hősök tere 14 8105 Pétfürdő Veszprém Hungary
  • NITRON LTD, Triq taz-Zwejt Office 2, Suite 2, The Penthouse, Capital Business Centre, Entrance C SGN 3000 San Gwann Malta
  • NOVOZYMES FRANCE, 60, route de Sartrouville Parc techno. des Grillons, bât 6 78232 LE PECQ Cedex France
  • NUTRIEN EUROPE S.A., Avenue Louise 326 (bte36) B - 1050 BRUXELLES Belgium
  • OCI Agro Belgium NV, Paniswijerstraat 92 3600 Genk Belgium
  • OCI Nitrogen B.V., Mijnweg 1 6167AC Geleen Netherlands
  • Octopod Invest Holding EAD, Maria Luisa 9 9000 Varna Varna Bulgaria
  • Origin Enterprises PLC, 4-6 Riverwalk Citywest Business Campus D24 DCW0 Dublin Ireland
  • OSTCHEM Germany GmbH Sev, Erdmannstr. 10 22765 Hamburg Germany
  • OSTCHEM Germany GmbH_Ch, Erdmannstr. 10 22765 Hamburg Germany
  • PARAMELT B.V., Costerstr. 18 1704 RJ Heerhugowaard Netherlands
  • Petrochemical Commercial Company (UK) Ltd, 24, GROSVENOR GARDENS SW1W 0DH LONDON EUROPE United Kingdom
  • PETROCHINA INTERNATIONAL (LONDON) CO., LTD, 11th Floor, The Adelphi, 1-11 John Adam Street, WC2N 6HT LONDON United Kingdom
  • Petrokemija d.d. Kutina, Aleja Vukovar 4 HR-44320 Kutina Croatia
  • PHOSINT LIMITED, 21 Vasili Michailidi 3026 Limassol Cyprus
  • PILOT CORPORATION OF EUROPE, PAE de la Caille 74350 ALLONZIER LA CAILLE France
  • Prasinus Holdings Ltd, ECOUREA 28 Dale Road, Sheriff Hutton YO60 6RZ York United Kingdom
  • Prefere Resins Finland Oy, Öljysatamantie 16 49401 Hamina Finland
  • Procter & Gamble Amiens S.A.S., 163/165 quai Aulagnier 92600 ASNIERES SUR SEINE France
  • Procter & Gamble Manufacturing GmbH, Sulzbacher Strasse 40 65824 Schwalbach am Taunus Germany
  • Procter & Gamble – Rakona s.r.o., Ottova 402 269 32 Rakovnik Czech Republic
  • Ramboll Environment & Health GmbH, Werinherstraße 79 Gebäude 32a 81541 München Germany
  • Reach & Colours s.r.o, Čelakovského sady 1580/4 Nové Město 110 00 Prague Czech Republic
  • Reach & Colours Trade Kft, Zahora utca 1/C 2161 Csomád Hungary
  • REACh ChemConsult GmbH, Strehlener Str. 14 01069 Dresden Germany
  • REACH GLOBAL SERVICES S.A., Rond Point Schuman, 6 B-1040 Brussels Belgium
  • Reach Only Representative (Ireland) Ltd (abqico), VPR House Main St F12 FC64 Swinford Co. Mayo Ireland
  • Reach Only Representative Ltd (liqcom), 20 Bostock Hall CW10 9JN Bostock Cheshire United Kingdom
  • REACH&Colours Kft, Petofi Sandor utca 11 I Em. 4 1052 Budapest Hungary
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin18 Dublin Ireland
  • REACH24H CONSULTING GROUP, Suite 1E, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • REACH24H CONSULTING GROUP, Paramount Court, Corrig Road, Sandyford Dublin 18 Dublin Ireland
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 02600 Espoo Finland
  • REACHLaw Ltd., Vänrikinkuja 3 JK 21 FI-02600 Espoo Finland
  • REACHLaw Ltd. (acting as OR for DNS Fine Chemicals & Lab Pvt. Ltd), Vänrikinkuja 3 JK 21 FI-02600 Espoo Finland
  • S.C. Chemgas Holding Corporation S.R.L., Sos. Calarasi km 4, Pavilion Administrativ 920120 Slobozia Ialomita Romania
  • S.C.GA- PRO- CO CHEMICALS S.A., UZINEI NR.2 617410 SAVINESTI Romania
  • SABIC Petrochemicals B.V., Europaboulevard 1 6135 LD Sittard Netherlands
  • SADEPAN CHIMICA NV, Henry Fordlaan 68 3600 Genk Belgium
  • Sadepan Chimica S.r.l., Viale Lombardia, 29 46019 Viadana Italy
  • SC AZOMURES SA, Gheorghe Doja 540237 TARGU MURES MURES Romania
  • sc donauchem srl, portului nr.1 145200 Turnu Magurele Teleorman Romania
  • SCIC MARTINIQUE SAS, POINTE DES CARRIERES 97200 FORT DE FRANCE MARTINIQUE France
  • SEGE SA, Ethnikis Antistaseos 84 15231 Chalandri Greece
  • SI Group UK (UKAA) Ltd, Tenax Road M17 1WT Manchester United Kingdom
  • Sigma-Aldrich Biochemie GmbH, Georg-Heyken-Str. 14 21147 Hamburg Germany
  • Sigma-Aldrich Chemie GmbH, Riedstrasse 2 89555 Steinheim Germany
  • SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany
  • SIGMA-ALDRICH CHIMIE SARL, 80 Rue de Luzais BP 701 38297 Saint Quentin Fallavier France
  • Sigma-Aldrich Company Limited, The Old Brickyard, New Road SP8 4XT Gillingham United Kingdom
  • Sigma-Aldrich Ireland Ltd, Vale Road . Arklow Co. Wicklow Ireland
  • Sigma-Aldrich Sweden AB, Solkraftsvägen 14C S-135 70 Stockholm Sweden
  • SKW Stickstoffwerke Piesteritz GmbH, Möllensdorfer Straße 13 06886 Lutherstadt Wittenberg Germany
  • SNF SA, ZAC de Milieux 42163 Andrézieux France
  • Société Française SOQUEBRA S.A., 7, rue Blaise Pascal 74600 SEYNOD France
  • Solenis Netherlands B.V., Fascinatio Boulevard 522 2909 VA CAPELLE A/D IJSSEL Netherlands
  • Specialty Electronic Materials Netherlands B.V., Herbert H. Dowweg 5 4542NM Hoek Netherlands
  • SpetsInterProject Oy Ammoniy, Näkinkaari 1 M 02320 Espoo Finland
  • SQM Europe N.V., Houtdok – Noordkaai 25a 2030 Antwerpen Belgium
  • Stahl Europe B.V., Sluisweg 10 5145PE Waalwijk Noord Brabant Netherlands
  • Sustainability Support Services (Europe) AB, Markaskälsvägen 6 22647 Lund Sweden
  • Tennants Distribution Limited, Hazelbottom Rd. Cheetham M8 0GR Manchester Greater Manchester United Kingdom
  • TFL Ledertechnik GmbH, Peter-Krauseneck-Strasse 16 79618 Rheinfelden Germany
  • The Acta Group EU BVBA (BE28), Place du Luxembourg 2 1050 Brussels Belgium
  • The Acta Group EU BVBA (BE30), Place du Luxembourg 2 1050 Brussels Denmark
  • The Acta Group EU BVBA (BE35), Place du Luxembourg 2 1050 Brussels Belgium
  • TIMAC AGRO, 27 Avenue Franklin Roosevelt BP 70158 35408 SAINT-MALO France
  • TIMAC AGRO BELUX, 4 rue de la Jonction 6030 Marchienne-au-Pont Belgium
  • TIMAC AGRO DUNGEMITTELPRODUCTIONS UND HANDELSGMBH, Industriegelände Pischelsdorf 3435 Zwentendorf Austria
  • TIMAC AGRO ESPAÑA SA, Pol. Arazuri-Orcoyen Calle C, n°32 31160 Orcoyen Spain
  • TIMAC AGRO ITALIA SPA, Strada Montodine Gombito 26010 Ripalta Arpina Cremona Italy
  • Tradiax GmbH, Mittelstrasse 1 58285 Gevelsberg Germany
  • Trammo SARL, 23 Rue Balzac 75008 Paris France
  • Triada Chem Ltd. , Riverside Two D02 KV60 Sir John Rogerson's Quay Dublin 2 Ireland
  • TSGE_2019-006, Lavesstraße 4 31137 Hildesheim Germany
  • TÜV SÜD Industrie Service GmbH, IS-USR-MUC Westendstraße 199 80686 Munich Germany
  • UAB "APLINKOS VADYBA", Vilkpėdės g. 22 03151 Vilnius Lithuania
  • UMCO GmbH, Georg-Wilhelm-Straße 187 21107 Hamburg Germany
  • Umena, Bachfeld 17 4211 Alberndorf Austria
  • UmEnA GmbH, Bachfeld 17 4211 Alberndorf in der Riedmark Upperaustria Austria
  • UmEnA GmbH, Bachfeld 17 4211 Alberndorf Austria
  • United Equipment Co. (UNEC) Ltd., Sardine Street SPB6073 Burmarrad Malta
  • Uralchem Assist, Johannssenstrasse 10 30159 Hannover Germany
  • Van Raak Chemicals nv, Toekomststraat 1 2381 Ravels (Weelde) Belgium
  • Wilfried Groll Beratun + Vermittlung für die Kunststoffverarbeitun, Eutiner Str. 13 26160 Bad Zwischenahn Germany
  • Witt Handel GmbH, Raboisen 6 20095 Hamburg Germany
  • Yara Brünsbuttel GmbH, Holstendamm 2 D-25572 Büttel Schleswig-Holstein Germany
  • Yara France, IMMEUBLE OPUS 12 77 ESPLANADE DU GENERAL DE GAULLE CS 90047 92914 PARIS LA DEFENSE CEDEX France
  • Yara Iberian, S.A., C/ Infanta Mercedes, 31-2º 28020 Madrid Spain
  • Yara International ASA OR1, Drammensveien 131 N-0277 Oslo Norway
  • Yara Italia SpA, Via Begnigno Crespi, 57 20159 Milano Italy
  • Yara Sluiskil B.V., Industrieweg 10 4541HJ Sluiskil Netherlands
  • Yordas Limited, Lancaster Environment Centre Lancaster University LA1 4YQ Lancaster United Kingdom
  • Yordas Limited, Lancaster Environment Centre LA1 4YQ Lancaster United Kingdom
  • B-Lands Consulting (811250-5), World Trade Center 5 Place Robert Schuman - BP 1510 38025 Grenoble France France
  • Borealis Agrolinz Melamine Deutschland GmbH, Möllensdorfer Str. 13 6886 Lutherstadt Wittenberg Germany
  • Borealis Chimie, 20 ter, rue de BEZONS 92400 COURBEVOIE France
  • GBZI UK & IRELAND LTD, Britannia House New Road ME12 1NB Sheerness Kent United Kingdom
  • GHS-expert Ltd, Háromszék u. 51. 1194 Budapest Hungary
  • GHS-expert Ltd., Háromszék u. 51. 1194 Budapest Hungary
  • Koch Fertilizer Products SAS, 44 ter Boulevard Saint Antoine 78150 Le Chesnay France
  • OSTCHEM Germany GmbH, Erdmannstr. 10 22765 Hamburg Germany
  • PETROBRAS EUROPE LIMITED., 9th Floor, 1 Angel Court EC2R 7HJ London United Kingdom
  • PETROBRAS GLOBAL TRADING BV - PGT BV, Weena 762 - 9th Floor, First Rotterdam 3014 DA Rotterdam Netherlands
  • Prinova Europe Limited, 10,Aldersgate Street EC1A 4HJ London United Kingdom
  • SCIC GUADELOUPE SARL, 1 RUE DE LA CHAPELLE ZI DE JARRY 97122 BAIE MAHAULT GUADELOUPE France
  • Unipetrol RPA, Litvinov - Zaluzi 1 43670 Litvinov Czech Republic

Other names

  • -
  • carbamide
  • carbammide
  • Carbonyl Diamide
  • CO(NH2)2
  • DIAMINOMETHANAL
  • Diaminomethanal (as organic compound), Carbonyl diamide (as inorganic compound)
  • Diaminomethanal, Carbamide
  • diamminomethanal
  • Everagent T138
  • HAS urea
  • UREA
  • urea and NPK fertilizer mult-constiuent substance of urea and ammonium dihydrogenorthophosphate and potassium dihydrogenorthophosphate
  • urea carbamide
  • Urea Pilot
  • Urea [for General Organic Chemistry]
  • Urea.
  • urea/ Diaminomethanal
  • Ureum
  • Carbamid
  • Carbamide
  • Carbamimidic acid
  • Carbomid
  • CARBON DIAMMIDE
  • Carbonildiamide
  • Carbonyl diamide
  • Carbonyl dyamide
  • carbonyldiamide
  • CROPOL UF100F
  • CROPOL UF100H
  • Everagent T138
  • Granular Urea
  • Harnstoff
  • Karbamid
  • Kohlensaeure-diamid
  • mocznik
  • mocznik granulowany 46%
  • mocznik techniczny krystaliczny
  • odczynniki - mocznik czysty
  • P1001
  • P4560
  • P4565
  • PIAGRAN 46
  • PiaNOx-U
  • PiaNOx-U granulated
  • prilled technical urea
  • Prilled Urea
  • roztwory saletrzano mocznikowe
  • Solución UAN
  • techniczny roztwór mocznika
  • URAFORM P1001
  • URAFORM P4560
  • URAFORM P4565
  • UREA
  • Urea (8CI, 9CI)
  • Urea 46% N
  • Urea ammonium nitrate solution (UAN)
  • Urea crystalline- pure
  • Urea feed
  • Urea feed-fine
  • UREA granular
  • Urea Prilled
  • Urea solution (AdBlue, GPNOX U, UREE SR)
  • Urea special quality
  • Urea technical
  • Urea technical, granulated
  • Urea, ferliliser grade
  • Urea, fine
  • Urea, Prilled
  • Urea, technical (LB)

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Study results
  • 1 study submitted
  • 1 study processed
C Physical state at 20°C and 1013 hPa
Solid (100%) [1]
C Form
Crystalline (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 1 summary submitted
  • 1 summary processed
Physical state at 20°C and 1013 hPa
Solid (100%)

Melting/freezing point

Study results
  • 2 studies submitted
  • 1 study processed
R Melting / freezing point
134 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Melting / freezing point at 101 325 Pa
133.85 °C

Boiling point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Density

Study results
  • 2 studies submitted
  • 1 study processed
R Relative density
1.33 @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Relative density at 20°C
1 330

Vapour pressure

Study results
  • 1 study submitted
  • 1 study processed
R Vapour pressure
0.002 Pa @ 25 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Vapour pressure
0.002 Pa @ 24.85 °C

Partition coefficient

Study results
  • 2 studies submitted
  • 1 study processed
R Log Pow
-1.73 @ 22 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Log Kow (Log Pow)
-1.73 @ 20 °C

Water solubility

Study results
  • 2 studies submitted
  • 1 study processed
R Water solubility (mass/vol.)
624 g/L @ 20 °C [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
Water solubility
624 g/L @ 20 °C

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Flash point

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Auto flammability

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Flammability

Study results
  • 2 studies submitted
  • 1 study processed
C Interpretation of results
Non flammable (100%) [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Flammability
Non flammable (100%)

Explosiveness

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidising

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Study results
  • 2 studies submitted
  • 1 study processed
C Dissociating properties
Yes (100%) [1]
R Dissociation constant
0.6 [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Viscosity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible 1
Sci. unjustified
Exposure cons.
Other
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Study results
  • 3 studies submitted
  • 3 studies processed
C Interpretation of results
Readily biodegradable (100%) [3]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2 1
Other
Data waiving
no waivers
C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Biodegradation in water
Readily biodegradable (100%)

Biodegradation in water & sediment - simulation tests

Study results
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Biodegradation in soil

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: aquatic / sediment

Study results
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 1 summary submitted
  • 0 summaries processed

No automatically processable data submitted

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

R Summaries
  • 2 summaries submitted
  • 2 summaries processed

The Predicted No-Effect Concentration (PNEC) value is the concentration of a substance below which adverse effects in the environment are not expected to occur. Please note that when more than one summary is provided, PNEC values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Hazard for Aquatic Organisms
Freshwater 47 - 470 µg/L (2)
Intermittent releases (freshwater) -
Marine water 47 µg/L (1)
Intermittent releases (marine water) -
Sewage treatment plant (STP) No hazard identified (1)
Sediment (freshwater) No exposure of sediment expected (1)
Sediment (marine water) No exposure of sediment expected (1)
Hazard for Air
Air No hazard identified (1)
Hazard for Terrestrial Organism
Soil No exposure of soil expected (1)
Hazard for Predators
Secondary poisoning No potential for bioaccumulation (1)

Short–term toxicity to fish

Study results
  • 4 studies submitted
  • 4 studies processed
P/RResults
LC50 (4 days) 6.81 - 22.5 g/L [3]
LC50 (72 h) 12.1 g/L [1]
LC50 (48 h) 10 - 17.86 g/L [2]
LC50 (24 h) 18.6 g/L [1]
LC0 (4 days) 20 g/L [1]

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 4
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
LC50 for freshwater fish
6.81 g/L

Long–term toxicity to fish

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Short–term toxicity to aquatic invertebrates

Study results
  • 4 studies submitted
  • 1 study processed
P/RResults
EC50 (24 h) 10 g/L [1]

Type of Study provided
Studies with data
Key study 1
Supporting study 3
Weight of evidence
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC50 / LC50 for freshwater invertebrates
10 g/L

Long–term toxicity to aquatic invertebrates

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to aquatic algae and cyanobacteria

Study results
  • 3 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 3
Other
Data waiving
no waivers
R Summaries
  • 2 summaries submitted
  • 2 summaries processed
EC10 or NOEC for freshwater algae
47 mg/L

Toxicity to aquatic plants other than algae

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 0 summaries submitted
  • 0 summaries processed

No data available

Toxicity to microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Sediment toxicity

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial arthropods

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to terrestrial plants

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study 1
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to soil microorganisms

Study results
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to birds

Study results
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Type of Study provided
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed

The derived no- or minimum effect level (DN(M)EL) is the level of exposure above which a human should not be exposed to a substance. Please note that when more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. More detailed information is available in the dossiers.

Data for WORKERS
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 292 mg/m³ developmental toxicity / teratogenicity
Acute /short term: (DNEL) 292 mg/m³ developmental toxicity / teratogenicity
Local Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 580 mg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: (DNEL) 580 mg/kg bw/day developmental toxicity / teratogenicity
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
EYE Exposure
No hazard identified
Data for the GENERAL POPULATION
INHALATION Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 125 mg/m³ developmental toxicity / teratogenicity
Acute /short term: (DNEL) 125 mg/m³ developmental toxicity / teratogenicity
Local Effects
Long-term: Hazard unknown (no further information necessary as no exposure expected)
Acute /short term: Hazard unknown (no further information necessary as no exposure expected)
DERMAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 580 mg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: (DNEL) 580 mg/kg bw/day developmental toxicity / teratogenicity
Local Effects
Long-term: No hazard identified
Acute /short term: No hazard identified
ORAL Exposure Threshold Most sensitive study
Systemic Effects
Long-term: (DNEL) 42 mg/kg bw/day developmental toxicity / teratogenicity
Acute /short term: (DNEL) 42 mg/kg bw/day developmental toxicity / teratogenicity
EYE Exposure
No hazard identified

Toxicokinetics, metabolism, and distribution

Study results
Study data: basic toxicokinetics
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: basic toxicokinetics
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Study data: dermal absorption
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: dermal absorption
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
M/C Summaries
  • 4 summaries submitted
  • 2 summaries processed
Absorption values
Dermal: 9.5 %

Acute toxicity

Study results
oral
  • 4 studies submitted
  • 2 studies processed
P/RResults
LD50 14 300 - 15 000 mg/kg bw (rat) [2]
LD50 11 500 - 13 000 mg/kg bw (mouse) [2]
M/CInterpretations of results
Not classified [2]

Type of Study provided
oral
Studies with data
Key study
Supporting study 2
Weight of evidence 2
Other
Data waiving
no waivers
inhalation
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons.
Other 1
dermal
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

dermal
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
other routes
  • 4 studies submitted
  • 0 studies processed

No automatically processable data submitted

other routes
Studies with data
Key study
Supporting study 4
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Irritation / corrosion

Study results
Study data: skin
  • 3 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study 1
Supporting study 2
Weight of evidence
Other
Data waiving
no waivers
Study data: eye
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: eye
Studies with data
Key study 1
Supporting study
Weight of evidence 1
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin
No adverse effect observed (not irritating)
Eye
No adverse effect observed (not irritating)

Sensitisation

Study results
Study data: skin
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: skin
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: respiratory
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: respiratory
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified
Exposure cons. 1
Other
M/C Summaries
  • 2 summaries submitted
  • 2 summaries processed
Skin sensitisation
No adverse effect observed (not sensitising)
Respiratory sensitisation
No adverse effect observed (not sensitising)

Repeated dose toxicity

Study results
Study data: oral
  • 2 studies submitted
  • 2 studies processed
P/RResults
NOAEL (rat): 45 000 ppm [1]
NOAEL (mouse): 45 000 ppm [1]

Type of Study provided
Study data: oral
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Study data: inhalation
  • 1 study submitted
  • 0 studies processed

No automatically processable data submitted

Study data: inhalation
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: dermal
  • 2 studies submitted
  • 0 studies processed

No automatically processable data submitted

Study data: dermal
Studies with data
Key study 2
Supporting study
Weight of evidence
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Genetic toxicity

Study results
Study data: in vitro
  • 8 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: in vitro
Studies with data
Key study
Supporting study 2
Weight of evidence 6
Other
Data waiving
no waivers
Study data: in vivo
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: in vivo
Studies with data
Key study
Supporting study 1
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Carcinogenicity

Study results
  • 2 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Studies with data
Key study
Supporting study
Weight of evidence 2
Other
Data waiving
no waivers
Summaries
  • 2 summaries submitted
  • 0 summaries processed

No automatically processable data submitted

Toxicity to reproduction

Study results
Study data: reproduction
  • 1 study submitted
  • 0 studies processed

Study data not processed for brief profile

Type of Study provided
Study data: reproduction
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: developmental
  • 5 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: developmental
Studies with data
Key study 1
Supporting study 2
Weight of evidence 1
Other
Data waiving
Not feasible
Sci. unjustified 1
Exposure cons.
Other
Study data: other studies
  • 0 studies submitted
  • 0 studies processed

Study data not processed for brief profile

Study data: other studies
Studies with data
Key study
Supporting study
Weight of evidence
Other
Data waiving
no waivers
M/C Summaries
  • 2 summaries submitted
  • 1 summary processed
Effect on developmental toxicity
Oral route:
No adverse effect observed NOAEL 1 000 mg/kg bw/day (subacute, rat)

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant