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EC number: 247-660-8 | CAS number: 26401-35-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Studies on repeated dose toxicity could not be identified for diisotridecyl adipate. Results for di-2-ethylhexyl adipate are used for read across.
NOAELs have only been determined for oral application.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEL
- 200 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- mouse
- Quality of whole database:
- Reliability 2
- Organ:
- other: decreased body weight gain
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- Reliability 3
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- Reliability 3
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- Reliability 4
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- Reliability 4
Additional information
For assessment of the repeated dose toxicity no valid study could be identified with diisotridecyl adipate as test substance. An aerosol inhalation study (Mobil, 1989) had only a test period of 14 days and relevant parameters were not examined (RL3). But studies concerning repeated dose toxicity are available for di-2-ethylhexyl adipate and ditridecyl adipate as supporting substances. Studies available are presented in the following table.
Study |
Guideline/ |
Species/ |
Duration |
Doses |
NOAEL |
Supp. Substance DEHA |
|
|
|
|
|
Miyata 2006 |
OECD 407 |
rat |
28 days |
40, 200,1000 mg/kg/day |
200 |
NTP 1982 |
subchronic study |
rat |
91 days |
1600, 3100, 6300, 12500, 25000 ppm |
551 (females) 630 (males) mg/kg bw/day |
NTP 1982 |
subchronic study |
mouse |
91 days |
1600, 3100, 6300, 12500, 25000 ppm |
200 |
NTP 1982 |
carcinogenesis study |
rat |
103 weeks |
12000, 25000 ppm (600, 1250 |
600 |
NTP 1982 |
carcinogenesis study |
mouse |
103 weeks |
12000, 25000 ppm (1750, 3570 |
|
Supp. Substance ditridecyl adipate |
|
||||
HPV TP 2003 |
rat |
90 days |
800, 2000 |
not identified |
In the NTP program, di-2-ethylhexyl adipate has been investigated thoroughly (subchronic and chronic studies, two species). The lowest NOAEL was determined for the 91 day study in mice based on reduced body weight gain. This value will be used to derive a NOAEL for diisotridecyl adipate.
Di-2-ethyhexyl adipate, a saturated branched chain aliphatic adipate diester, is used as supporting substances for read across based on the close structural relationship to diisotridecyl adipate as substantiated in more detail in the endpoint summary of Section 7.1.1 - Basic toxicokinetics.
Justification for classification or non-classification
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