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EC number: 247-660-8
CAS number: 26401-35-4
skin reactions at all were observed neither during induction exposures
nor after challenge exposure.
The dermal sensitization potential of
diisotridecyl adipate was tested with human volunteers using a repeated
insult patch test. 104 human subjects (19 males and 85 females ) were
divided into two groups (49 and 55 subjects) for semi-occlusive and
occlusive application of test patches.
Induction exposure consisted of nine
repeated 24 h exposures at the same site (left upper back). Test
substance was administered on saturated patches (0.2 mL test substance)
on Monday, Wednesday, and Friday for 3 weeks followed by a rest period
of 2 weeks. After a single challenge exposure (24 h) on a virgin patch
site (upper right back), the challenge reaction was evaluated 24, 48,
and 72 hours after patch application.
No skin reaction in any of the 104
test subjects was observed either during induction exposure nor at any
of the challenge readings.
In this study, diisotridecyl
adipate did not exhibit any dermal sensitizing potential in humans
This study is classified as acceptable
as it follows established procedures for a repeated insult patch test.
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