2-(diethylamino)ethyl methacrylate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1981-9-30 - 1981-10-22

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline compliant study.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1982

Report date:

1982

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

no

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-(diethylamino)ethyl methacrylate

EC Number:

203-275-7

EC Name:

2-(diethylamino)ethyl methacrylate

Cas Number:

105-16-8

Molecular formula:

C10H19NO2

IUPAC Name:

2-(diethylamino)ethyl methacrylate

Test material form:

other: liquid

Test animals

Species:

rat

Strain:

Crj: CD(SD)

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Age at study initiation: 7-8 weeks old
- Weight at study initiation: 230-270 g
- Fasting period before study:
- Housing: housed in pairs in stainless steal wire mesh cages
- Diet: Purino Rodent Chow #5002, ad libitum
- Water: ad libitum
- Acclimation period: 1 week

Administration / exposure

Route of administration:

inhalation: aerosol

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus:
- Exposure chamber volume:
- Method of holding animals in test chamber:
- Source and rate of air:
- Method of conditioning air:
- System of generating particulates/aerosols:

TEST ATMOSPHERE
- Brief description of analytical method used:
- Samples taken from breathing zone: yes

Analytical verification of test atmosphere concentrations:

yes

Duration of exposure:

4 h

Concentrations:

0.4, 0.7, 1.1, 1.4, 1.8 mg/L

No. of animals per sex per dose:

10 male animals per dose

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LC50

Effect level:

1.8 mg/L air

Based on:

test mat.

Exp. duration:

4 h

Mortality:

At concentrations groups 0.4 - 1.8 no mortality occurred. At the highest dose group, 1.8 mg/L, 7 out of 10 animals died.

Clinical signs:

other: During exposure: All rats exhibited a clear nasal and oral discharge. Rats exposed exposed to 0.7 mg/L or greater exhibited hyperplasia of the extremities. Rats exposed to 1.1. mg/L or greater exhibited labored breathing, sporadic tremors, and convulsions

Body weight:

Rats exposed to 0.4 mg/L exhibited slight weight loss but showed no adverse clinical signs. Rats exposed to higher concentrations exhibited slight to severe weight loss lasting 1 to 4 days post exposure, followed by the resumption of a normal rate of weight gain.

Gross pathology:

No data

Any other information on results incl. tables

An approximate lethal concentration of 1.8 mg/L was determined for the test substance.