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EC number: 203-275-7
CAS number: 105-16-8
In an acute oral toxicity test the test substance performed according to OECD guideline 423 (BASF SE, 2015) a LD50 value of > 300 < 2000 mg/kg bw was determined. In an acute inhalation toxicity test with the test substance (aerosol) performed similarily to OECD guideline 403 (Haskell Laboratories, 1981) a LC50 of 1.8 mg/L was determined.
An approximate lethal concentration of
1.8 mg/L was determined for the test substance.
Acute toxicity oral
In an acute
oral toxicity study performed according to the Acute Toxic Class method, doses
of 2000 and 300 mg/kg bw of the test item Diethylaminoethyl Methacrylate (preparations
in corn oil (20% of the test substance) were administered by gavage to
three test groups of three fasted Wistar rats each (2000 mg/kg bw in 3
females, 300 mg/kg bw in 6 females). At
2000 mg/kg bw 2 of 3 animals died, at 300 mg/kg bw all animals survived. The
acute oral LD50 was
calculated to be LD50,
oral, rat > 300 < 2000 mg/kg bw (BASF
A single dose oral toxicity test with
a read-across (RA) substance was performed according to OECD guideline
401. The RA test substance in corn oil was administered (gavage) in
concentrations of 500, 100 and 2000 mg/kg bw to 5 males and 5 females
rats per dose group. No mortality occurred in any of the treated groups.
At necropsy, raised patches in the forestomach were observed in males of
the 2000 mg/kg group. In the histopathological examination papiflomatous
hyperplasia in the forestomnach was apparent. A LD50 value of > 2000
mg/kg bw was determined.
Acute toxicity inhalation
Groups of 10 male rats were exposed (whole
body) to aerosol of the test substance for 4 hours in concentrations of
0.4, 0.7, 1.1, 1.4, 1.8 mg/L.
At concentrations groups 0.4 - 1.8 no
mortality occurred. At the highest dose group, 1.8 mg/L, 7 out of 10
During exposure: All rats exhibited a clear
nasal and oral discharge. Rats exposed exposed to 0.7 mg/L or greater
exhibited hyperplasia of the extremities. Rats exposed to 1.1. mg/L or
greater exhibited labored breathing, sporadic tremors, and convulsions.
Post exposure: Rats exposed to 0.4 mg/L
exhibited slight weight loss but showed no adverse clinical signs. Rats
exposed to higher concentrations exhibited slight to severe weight loss
lasting 1 to 4 days post exposure, followed by the resumption of a
normal rate of weight gain. Rats exposed to 0.7 mg/L exhibited a clear
nasal and oral discharge. At higher concentrations, rats exhibited red
nasal discharge, labored breathing, lung noise, and cloudy eyes lasting
4 – 14 days post exposure. Severity and persistence of symptoms were
proportional to exposure concentration.
Under the study conditions, an approximate
lethal concentration of 1.8 mg/L was determined for the test substance.
The available studies were
considered reliable and suitable for classification purposes under
67/548/EEC. As a result the substance is considered to be classified
as Xn; R20/22 under Directive 67/548/EEC, as amended for the 31st
time in Directive 2009/2/EG.
and Packaging Regulation (EC) No 1272/2008
The available experimental test
data are reliable and suitable for classification purposes under
Regulation 1272/2008. As a result the substance is considered to be
classified as acute Tox. 4; H302: Harmful if swallowed. and Acute
Tox. 4; H332: Harmful if inhaled under Regulation (EC) No.
1272/2008, as amended for the sixth time in Regulation EC 605/2014.
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