Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-881-4 | CAS number: 128-37-0
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: publication which does not give sufficient experimental details
Data source
Reference
- Reference Type:
- publication
- Title:
- Lung toxicity and tumor promotion by hydroxylated derivatives of 2,6-di-tert-Butyl-4methylphenol (BHT) and 2-tert-Butyl-4-methyl-6-iso-propylphenol: Correlation with Quinone methide reactivity
- Author:
- Kupfer, R.; Dwyer-Nield, L., D.; Malkinson, A., M.; Thompson, J., A.
- Year:
- 2 002
- Bibliographic source:
- Chem. Res. Toxicol., 15, 1106-1112
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- other: toxicity study, single injection (i.p.) of BHT
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 2,6-di-tert-butyl-p-cresol
- EC Number:
- 204-881-4
- EC Name:
- 2,6-di-tert-butyl-p-cresol
- Cas Number:
- 128-37-0
- Molecular formula:
- C15H24O
- IUPAC Name:
- 2,6-di-tert-butyl-4-methylphenol
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Balb/c
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- corn oil
- Doses:
- 0, 100, 150, 200 mg/kg
and 200 mg/kg - No. of animals per sex per dose:
- 5 per group
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- other: maximum tolerated dose, single i.p. injection
- Effect level:
- 200 mg/kg bw
Any other information on results incl. tables
100 mg/kg BHT had no significant effect on the lung weight: body weight ratio, but 200 mg/kg was effective
Histologic analysis of lungs: BHT produced compensatory type 2 cell hyperplasia and macrophage infiltration
Applicant's summary and conclusion
- Executive summary:
MTD (i.p.): 200 mg/kg bw (Kupfer, 2002).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
