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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Epidemiological data

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Administrative data

epidemiological data
Type of information:
experimental study
Adequacy of study:
supporting study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: acceptable, well-documented publication which meets basic scientific principles

Data source

Reference Type:
Intake of butylated hydroxyanisole and butylated hydroxytoluene and stomache cancer risk: Results from analyses in the Netherlands Cohort Study
Botterweck, A., A., M. et al.
Bibliographic source:
Food and Chemical Toxicology, 38, 599-605

Materials and methods

Study type:
cohort study (prospective)
Endpoint addressed:
Principles of method if other than guideline:
other: cohort study
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
EC Number:
EC Name:
Cas Number:
Molecular formula:
Details on test material:
Information on BHA and/or BHT content was obtained by chemical analysis of selected potential BHA- and or BHT containing food and by the use of two other information sources: a Dutch database of food additives for people with food intolerance and allergy (ALBA) and the durch Compendium of Food and Diet Products (Compendium of Food and Diet Products, 1989/1990)


Details on study design:
The Netherland cohort study on diet and cancer (NLCS) is a prospective cohort study which started in September 1986 among the general population in the Netherlands. The cohort included 62573 women and 58279 men aged 55 to 69 yr in 1986. At baseline, the cohort members completed a mailed, self-administered questionnaire on dietary habilts, smoking, occupation, medical history, personal and family history of cancer, and demopraphic data.
Exposure assessment:

Results and discussion

In this study, no significant association with stomach cancer risk was found for usual intake of low levels of BHA and BHT.

Any other information on results incl. tables

After 6.3 years of follow-up, complete data on BHT intake of 192 incident stomach cancer cases and 2035 subcohort members were available for case-cohort analysis. Mean intake of BHA or BHT among subcohort members was 105 and 351 µg/day, respectively. For consumption of mayonnaise and other creamy salad dressings with BHA or BHT no association with stomach cancer risk was observed. A statistically non-significant decrease in stomach cancer risk was observed with increasing BHA and BHT intake. In this study, no significant association with stomach cancer risk was found for usual intake of low levels of BHA and BHT.

Applicant's summary and conclusion