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EC number: 204-881-4 | CAS number: 128-37-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Epidemiological data
Administrative data
- Endpoint:
- epidemiological data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable, well-documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Intake of butylated hydroxyanisole and butylated hydroxytoluene and stomache cancer risk: Results from analyses in the Netherlands Cohort Study
- Author:
- Botterweck, A., A., M. et al.
- Year:
- 2 000
- Bibliographic source:
- Food and Chemical Toxicology, 38, 599-605
Materials and methods
- Study type:
- cohort study (prospective)
- Endpoint addressed:
- carcinogenicity
- Principles of method if other than guideline:
- other: cohort study
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,6-di-tert-butyl-p-cresol
- EC Number:
- 204-881-4
- EC Name:
- 2,6-di-tert-butyl-p-cresol
- Cas Number:
- 128-37-0
- Molecular formula:
- C15H24O
- IUPAC Name:
- 2,6-di-tert-butyl-4-methylphenol
- Details on test material:
- Information on BHA and/or BHT content was obtained by chemical analysis of selected potential BHA- and or BHT containing food and by the use of two other information sources: a Dutch database of food additives for people with food intolerance and allergy (ALBA) and the durch Compendium of Food and Diet Products (Compendium of Food and Diet Products, 1989/1990)
Constituent 1
Method
- Details on study design:
- The Netherland cohort study on diet and cancer (NLCS) is a prospective cohort study which started in September 1986 among the general population in the Netherlands. The cohort included 62573 women and 58279 men aged 55 to 69 yr in 1986. At baseline, the cohort members completed a mailed, self-administered questionnaire on dietary habilts, smoking, occupation, medical history, personal and family history of cancer, and demopraphic data.
- Exposure assessment:
- measured
Results and discussion
- Results:
- In this study, no significant association with stomach cancer risk was found for usual intake of low levels of BHA and BHT.
Any other information on results incl. tables
After 6.3 years of follow-up, complete data on BHT intake of 192 incident stomach cancer cases and 2035 subcohort members were available for case-cohort analysis. Mean intake of BHA or BHT among subcohort members was 105 and 351 µg/day, respectively. For consumption of mayonnaise and other creamy salad dressings with BHA or BHT no association with stomach cancer risk was observed. A statistically non-significant decrease in stomach cancer risk was observed with increasing BHA and BHT intake. In this study, no significant association with stomach cancer risk was found for usual intake of low levels of BHA and BHT.
Applicant's summary and conclusion
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