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EC number: 204-881-4 | CAS number: 128-37-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key studies: Read-across from experimental data on the analogue 2,2',6,6'-tetra-tert-butyl-4,4'-methylenediphenol.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Read-across from an analogue substance for which a guideline study (Klimisch 2) is available.
- Reason / purpose for cross-reference:
- read-across source
- Principles of method if other than guideline:
- Read-across from company data on an analogue.
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: Based on a read-across from an analogue substance.
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: Based on a read-across from an analogue substance
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a 4 hour rabbit skin irritancy test, the test material (source chemical) caused no skin reactions and is therefore not a skin irritant. The read across approach is applied and the target chemical BHT is considered to be non-irritant for the skin.
- Executive summary:
The analogue CAS No. 118-82-1 (2,2',6,6'-tetra-tert-butyl-4,4'-methylenediphenol) which shares the same functional group (alkylphenol) with the substance CAS no. 128-37-0 (2,6-di-tert-butyl-p-cresol), also has comparable values for the relevant molecular properties. Therefore, the results obtained with the substance CAS No. 118-82-1 can be used for the read-across approach.
Based on company data, the read-across approach is applied from 2,2',6,6'-tetra-tert-butyl-4,4'-methylenediphenol and the substance 2,6 -di-tert-butyl-p-cresol (BHT) is considered to be non-irritant for the skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation, other
- Remarks:
- read-across from supporting subtance
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Read-across from an analogue substance for which a guideline study (Klimisch 2) is available.
- Reason / purpose for cross-reference:
- read-across source
- Principles of method if other than guideline:
- Read-across from company data on an analogue
- GLP compliance:
- yes
- Remarks on result:
- other: Read across, see cross reference to source information
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In the rabbit eye irritancy test, the test material (source chemical) caused slight conjunctival redness within 1 hour of dosing which had cleared by 24 hours. The test material is therefore not an eye irritant in rabbits. The read across is applied and the target chemical BHT is considered to be non-irritant for the eyes.
- Executive summary:
The analogue CAS No. 118-82-1 (2,2',6,6'-tetra-tert-butyl-4,4'-methylenediphenol)which shares the same functional group (alkylphenol) with the substance CAS no. 128-37-0 (2,6-di-tert-butyl-p-cresol), also has comparable values for the relevant molecular properties. Therefore, the results obtained with the substance CAS No. 118-82-1 can be used for the read-across approach.
Based on company data, the read-across approach is applied from 2,2',6,6'-tetra-tert-butyl-4,4'-methylenediphenol and the substance 2,6 -di-tert-butyl-p-cresol (BHT) is considered to be non-irritant for the eyes.
Reference
The results are presented in the cross reference to the source information (read-across).
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The analogue CAS No. 118-82-1 (2,2',6,6'-tetra-tert-butyl-4,4'-methylenediphenol) which shares the same functional group (alkylphenol) with the substance CAS no. 128-37-0 (2,6-di-tert-butyl-p-cresol), also has comparable values for the relevant molecular properties. Therefore, the results obtained with the substance CAS No. 118-82-1 can be used for the read-across approach.
Key study: Read-across from the analogue CAS No. 118-82-1: Skin irritation: In the 4 hour rabbit skin irritancy test, the test material caused no skin reactions and is therefore not a skin irritant.
Key study: Read-across from the analogueCAS No. 118-82-1 :Eye irritation: In the rabbit eye irritancy test, the test material caused slight conjunctival redness within 1 hour of dosing which had cleared by 24 hours. The test material is therefore not an eye irritant in rabbits.
Justification for classification or non-classification
Based on the available data, the substance is not classified as skin irritant or eye irritant.
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