2,6-di-tert-butyl-p-cresol

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:

direct observations: clinical cases, poisoning incidents and other

Type of information:

other: case report

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: case report, publication does not give sufficient details

Data source

Reference

Reference Type:

publication

Title:

Toxicity of butylated hydroxytoluene

Author:

Shlian, D., M.; et al.

Year:

1986

Bibliographic source:

The New England Journal of Medicine, vol. 314, 648-649

Materials and methods

Study type:

clinical case study

Endpoint addressed:

acute toxicity: oral

Principles of method if other than guideline:

other: case study

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2,6-di-tert-butyl-p-cresol

EC Number:

204-881-4

EC Name:

2,6-di-tert-butyl-p-cresol

Cas Number:

128-37-0

Molecular formula:

C15H24O

IUPAC Name:

2,6-di-tert-butyl-4-methylphenol

Details on test material:

no data

Method

Subjects:

22-year old white woman

Route of exposure:

oral

Reason of exposure:

intentional

Exposure assessment:

estimated

Results and discussion

Clinical signs:

case report

Any other information on results incl. tables

Case of gastritis caused by ingestion of BHT; a 22 -year old white woman ingested 4 g BHT on an empty stomach. Later that evening, she experienced severe epigastric cramping, generalized weakness, nausea and vomiting, followed by dizziness, confusion and a brief loss of consicousness. She was admitted in a dehydrated condition with epigastric burning pain. On admission, the patient's blood pressure was 110/70 mm Hg, with moderate orthostatic changes. The stool guaiac test was negative. She was afebrile, white-cell count of 7400, a normal differential cell count and a hematocrit of 35.8. The results of liver function test, electrolyte measurement, electrocardiography, and electroencephalography were within normal limits. Treatment included hydration, prochlorperazine, and antacids; the symptoms were resolved within a few days.