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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Basic data given

Data source

Reference
Reference Type:
publication
Title:
Toxicity of methyl-, ethyl-, and n-butyl methacrylate.
Author:
Deichmann W
Year:
1941
Bibliographic source:
J. Ind. Hyg. Toxicol. 23: 343-351

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Study to assess the acute oral toxicity of the test substance in rats before guideline development.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed

Test animals

Species:
rat
Strain:
other: albino
Sex:
not specified
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: own breeding
- Housing: Individual cages were used for housing rabbits and guinea pigs.
- Diet: rigidly controlled diet of Purina Rabbit or Fox Chow

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Details on oral exposure:
no data
Doses:
8420, 9360, 10300 and 11230 mg/kg bw (corresponding to 9 - 12 mL/kg bw and 0.084 - 0.112 mol/kg bw, respectively)
No. of animals per sex per dose:
10 animals of unknown sex per dose
Control animals:
no
Details on study design:
Of the surviving animals, some were killed about a week after the treatment and studied for pathological tissue changes. All animals that died were examined.
Statistics:
LD50 values were calculated by the method of Bliss (1938).

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 7 900 mg/kg bw
Remarks on result:
other: corresponding to 8.41 mL/kg bw
Mortality:
8420 mg/kg bw: 6/10 animals died 7 to 80 hrs after application
9360 mg/kg bw: 7/10 animals died 8 to 40 hrs after application
10300 mg/kg bw: 10/10 animals died 8 to 24 hrs after application
11230 mg/kg bw: 9/10 animals died 8 to 32 hrs after application
Clinical signs:
Lethal doses produced a constant train of disturbances. The animals showed an increased rate of respiration (with lacrimation in rats) in  about 2 to 5 minutes, followed by motor weakness and decreased respiration in 15 - 40 minutes. Subsequently, respiration became shallow, irregular and labored and there were increased defecation and urination. Reflex activity was lost and the animals died in coma. The rats urine usually contained blood.
Body weight:
not measured
Gross pathology:
not reported

Applicant's summary and conclusion