Registration Dossier
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EC number: 201-297-1 | CAS number: 80-62-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 0.94 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 0.94 mg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.094 mg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 10 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 10.2 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.102 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 1.48 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
PNEC aqua (freshwater)
Acute toxicity studies were conducted with MMA in fish, daphnia and algae. Chronic studies with MMA are available for all trophic levels.The PNEC aqua (freshwater) was based on the NOEC of 9.4 mg/L. An assessment factor of 10 was applied to the NOEC to calculate the PNEC aqua (freshwater) in accordance with Guidance on information requirements and chemical safety assessment, Chapter R.10: Characterisation of dose [concentration]-response for environment, 2008.
PNEC aqua (marine)
No tests with marine species are available. The PNEC aqua (marine water) was based on the NOEC of 9.4 mg/L. An assessment factor of 100 was applied to the NOEC to calculate the PNEC aqua (marine water) in accordance with Guidance on information requirements and chemical safety assessment, Chapter R.10: Characterisation of dose [concentration]-response for environment, 2008.
PNEC aqua (intermittent releases)
The most sensitive species for acute toxicity testing was Daphnia magna (EC50 = 69 mg/L). Using the default assessment factor of 100, a PNEC of 0.69 mg/L would be derived for intermittent releases. This value is lower than the chronic PNEC and, hence, makes no sense. Instead , the chronic PNEC is used as the departure point for the assessment of intermittent releases.
PNEC STP
The calculation of the PNEC STP is based on the result of a biodegradation study. At 100 mg/L MMA was biodegraded by 94 % without apparent microbial toxicity. An AF of 10 is applied.
PNEC sediment (freshwater, marine)
No toxicity data for sediment dwelling organisms are available. Thus, the PNEC for freshwater as well as marine sediment has been calculated with the equilibrium partitioning method using EUSES 2.1.
The following data have been taken into account for the calculation:
Molecular weight [g/mol] | 100.12 |
Melting point [°C] | -48 |
Boiling point [°C] | 100.36 |
Vapour pressure [hPa], 20°C | 37.0 |
Water solubility [mg/L], 25°C | 15300 |
Log Kow | 1.38 |
Koc (Kow method) L/kg | 72 |
PNEC aqua, freshwater [mg/L] | 0.94 |
PNEC air
A PNEC air was not calculated for MMA since the substance is rapidly degraded in air. This indicates that there would be only little accumulation of the test substance in the air.
PNEC soil
No toxicity data for soil organisms are available. Thus, the PNEC soil has been calculated with the equilibrium partitioning method using EUSES 2.1.
The following data have been taken into account for the calculation:
Molecular weight [g/mol] | 100.12 |
Melting point [°C] | -48 |
Boiling point [°C] | 100.36 |
Vapour pressure [hPa], 20°C | 37.0 |
Water solubility [mg/L], 25°C | 15300 |
Log Kow | 1.38 |
Koc (Kow method) L/kg | 72 |
PNEC aqua, freshwater [mg/L] | 0.94 |
PNEC oral
A PNEC oral was calculated for MMA but not considered with respect to secondary poisening, since the substance is readily biodegradable. Due to the well investigated metabolic pathways the probability of being rapidly metabolised in exposed organisms is high. Together with the reported log Kow of 1.38 this indicates that there would be no significant potential for biomagnification of the test substance in the food chain.
Conclusion on classification
According to the criteria of the CLP (EU-GHS) Directive 1272/2008 classification regarding hazards for the aquatic environment is not required.
According to the criteria of the GHS classification (GHS UN rev.3, 2009) MMA has to be classified for acute aquatic toxicity, category 3.
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