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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

LC50 fish (96h): > 100 mg/l (lepomis macrochirus)

NOEC fish (35 d): 9.4 mg/l (Danio rerio)

EC50 daphnia (48h): 69 mg/l

NOEC daphnia (21d): 37 mg/l

ErC50 algae (72h): > 110 mg/l (Pseudokircheriella supcapitata)

NOEC algae (72h): 110 mg/l (Pseudokircheriella supcapitata)

NOEC microorganisms: > 100 mg/l

Additional information

Data availability:

For MMA acute as well as chronic studies of sufficient reliability are available for all three trophic levels, as well as reliable microbial toxicity data.



Two flow through acute toxicity studies to fish are available with methyl methacrylate. Bowman (1990) tested oncorynchus mykiss for 96 hrs in concentrations up to 79 mg/l (meas. conc.) . No mortality was observed in this test.

A second study (Bailey et al, 1985) tested methyl methacrylate in concentrations above 100 mg/l to lepomis macrochirus. LC 50 (96 h) was evaluated with 191 mg/l (arithm. mean meas. conc.).

Based on these results LC50 fish (96h) of methyl methacrylate is > 100 mg/l.

Chronic aquatic toxicity to fish (Schäfers, 2002) of methyl methacrylate was tested in a fish early life stage test acc. OECD 210 under flow through conditions with Danio rerio at nominal test concentration of 9.38, 18.8, 37.5, 75.0, and 150 mg/L. After 35 days, the NOEC (nominal conc.) was 9.4 mg/L based on hatching, weight and length, the LOEC (hatch, weight and length) was 18.8 mg/.

LC50 and LC10 based on mortality were 33.7 mg/L and 16.9mg/L, respectively.

Daphnia magna:

In a guideline study according EPA OTS 797.1300 (Burgess, 1990), the toxicity to Daphnia magna of MMA was tested in nominal concentrations of 7.2, 14, 30, 60 and 120 mg/l (corresponding to measured concentrations calculated from analytical sampling at 0 and 48 hrs of 5.2, 11, 23, 48 and 100 mg/l). No immobilization was observed in concentrations up to 48 mg/l, 100 % immobilization occurred at 100 mg/l. EC50 Daphnia magna (48h) was calculated to be 69 mg/l.


The 21-day-chronic toxicity of methyl methacrylate to Daphnia magna Straus was studied under flow through conditions according to OECD guideline 211 (cited as OECD Guideline 202, part 2 (Daphnia sp., Reproduction Test). Daphnids were exposed to the test chemical at nominal test concentration of 13, 25, 50, 100 and 200 mg/L corresponding to measured concentrations of 3.9, 10, 18, 37 and 68 mg/L

The 21-d EC50 based on mortality was 49 mg/l ( corresponding 95 % confidence limit calculated by binominal probability of 37 to 68 mg).

The 21-day NOEC based on reproduction was 37 mg/l. Daphnid reproduction was not adversely affected by exposure to concentrations less than those affecting daphnid survival.



In a 72 hour acute toxicity study (Smyth & Long, 1999), the cultures of Pseudokircheriella subcapitata were exposed to methyl methacrylate at measured concentrations of 3.6, 9.7, 22, 49, 110 mg/L under static conditions in acc. with OECD 301 (adopted 12 December 1992). Substance loss during the test was 6 -13 %.

EC50 (72h) based on growth rate was > 110 mg/l, NOEC (72h) based on growth rate was 110 mg/l.