Propylidynetrimethanol

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: meets gereally accepted criteria, but individual data are not shown

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1956

Report date:

1956

Materials and methods

Principles of method if other than guideline:

Groups of 4 albino rabbits were evaluated for acute dermal toxicity following single dermal application for 24 hours and a post exposure observation period of 7 days; gross autopsy

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Propylidynetrimethanol

EC Number:

201-074-9

EC Name:

Propylidynetrimethanol

Cas Number:

77-99-6

Molecular formula:

C6H14O3

IUPAC Name:

2-ethyl-2-(hydroxymethyl)propane-1,3-diol

Details on test material:

the test substance was considered of 100 "% purity

Test animals

Species:

rabbit

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 1.5-2.5 kg
- Housing: individually
- Diet ad libitum
- Water ad libitum:

Administration / exposure

Type of coverage:

occlusive

Vehicle:

water

Details on dermal exposure:

the material was moistened with water to form a paste; the paste was spread evenly on a non-absorbent paper backing which was applied to the closely clipped intact abdominal skin. The trunks were then wrapped securely with a gauze and adhesive tape binder for 24 hours. After removal of the binder the skin was rinsed with water in order to remove any residues. The animals were observed for 7 days

Duration of exposure:

24 hours

Doses:

1000, 2150, 4640, 10000 mg/kg bw

No. of animals per sex per dose:

4 per dose

Control animals:

not specified

Details on study design:

the material was moistened with water fo form a paste; the paste was spread evenly on a non-absorbent paper backing which was applied to the closely clipped intact abdominal skin. The trunks were then wrapped securely with a gauze and adhesive tape binder for 24 hours . After removal of the binder the skin was rinsed with water in order to remove any residues. The animals were observed for 7 days

Statistics:

no data all aninals survived

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 10 000 mg/kg bw

Based on:

other: no mortality occurred

Remarks on result:

other: no mortality

Mortality:

no

Clinical signs:

other: a very mild degree of dermal irritation which disappeared at the next day, no other signs were observed

Gross pathology:

1000 mg/kg bw: no findings
2150, 4640, 10000 mg/kg bw::
the kidneys of the majority of the rabbits contained hyperemic zone at the cortico-medullary junction , no other findings

Other findings:

no data

Applicant's summary and conclusion

Executive summary:

Groups of 4 albino rabbits were evaluated for acute dermal toxicity followling single dermal application

of 1000, 2150, 4640, 10000 mg/kg bw as paste for 24 hours and a post exposure observation period of

7 days. A very mild degree of dermal irritation which disappeared at the next day was the only clinical finding;

no animal died. Gross autopsy showed histopathological changes only in the kidneys from 2150 mg/kg bw

onwards. In the absence of any deaths, the LD50 value after single dermal administration is >10000 mg/kg bw (Celanese Corporation 1956).