Registration Dossier
Registration Dossier
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EC number: 201-074-9 | CAS number: 77-99-6
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- sub-chronic toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: insufficient reporting for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Maximum permissible concentration of trimethylolpropane (etriol) in factory air
- Author:
- Stankevich, V.V.:
- Year:
- 1 967
- Bibliographic source:
- Hygiene and Sanitation 32(5), 288-291
Materials and methods
- Principles of method if other than guideline:
- daily application to the skin of rabbits for 4 hours (no further data) or the tail was immersed in an aquous solution daily for 4 hours .
observation for effects - GLP compliance:
- no
Test material
- Reference substance name:
- Propylidynetrimethanol
- EC Number:
- 201-074-9
- EC Name:
- Propylidynetrimethanol
- Cas Number:
- 77-99-6
- Molecular formula:
- C6H14O3
- IUPAC Name:
- 2-ethyl-2-(hydroxymethyl)propane-1,3-diol
- Details on test material:
- no further data
Constituent 1
Test animals
- Species:
- other: rabbits and mice
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on exposure:
- Route of Administration: dermal exposure time: daily 4 hours
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- no data
- Duration of treatment / exposure:
- 3 months
- Frequency of treatment:
- daily 4 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.5 ml of 50 % aqueous solution/animal/d
Basis:
- No. of animals per sex per dose:
- no data for rabbits and no data for mice
- Control animals:
- other: no data specified
- Details on study design:
- Post-exposure period: no data
- Positive control:
- no data
Examinations
- Observations and examinations performed and frequency:
- reactions on skin and behavior
- Sacrifice and pathology:
- no data
- Other examinations:
- no data
- Statistics:
- no data
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Dermal irritation:
- no effects observed
- Mortality:
- no mortality observed
- Body weight and weight changes:
- no effects observed
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Details on results:
- RS-Freetext: no visible effect at the site of application, no change in the general condition of the animals
Effect levels
- Dose descriptor:
- conc. level: 50% aquous solution
- Effect level:
- 50 other: % aquous solution
- Sex:
- not specified
- Basis for effect level:
- other: no effects were observed
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
no visible effect at the site of application, no change in
the general condition of the animals
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
