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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: scientific acceptable but short documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1965
Report date:
1965

Materials and methods

Principles of method if other than guideline:
The test substance was dissolved in ethanol/lutrol (1:1) and dynamically sprayed into an inhalation apparatus. For each concentration 20 male rats were used. Duration of exposure was 4 hours and the post exposure observation time 14 days.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Propylidynetrimethanol
EC Number:
201-074-9
EC Name:
Propylidynetrimethanol
Cas Number:
77-99-6
Molecular formula:
C6H14O3
IUPAC Name:
2-ethyl-2-(hydroxymethyl)propane-1,3-diol
Details on test material:
no data

Test animals

Species:
rat
Strain:
not specified
Sex:
male
Details on test animals or test system and environmental conditions:
no further data

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
whole body
Vehicle:
other: ethanol/lutrol (1:1)
Details on inhalation exposure:
the test substance was disolved in ethanol/lutrol (1:1) and dynamically sprayed into an inhalation apparatus; no further data
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
4 h
Concentrations:
0.59 mg/liter or 0.85 mg/liter (analytical)
2.5 mg/liter or 5.0 mg/liter (nominal)
No. of animals per sex per dose:
20 male rats per concentration
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Other examinations performed: clinical signs, body weight
Statistics:
no data - all animals survived

Results and discussion

Effect levels
Dose descriptor:
LC50
Effect level:
> 0.85 mg/L air
Based on:
other: no mortality was observed
Exp. duration:
4 h
Remarks on result:
other: none of the rats died
Mortality:
none of the animals died
Clinical signs:
other: no symptoms of poisoning were reported
Body weight:
0.58 mg/l: start 235 g ,end 254 g (avarage weight)
0.85 mg/l: start 206 g ,end 239 g (avarage weight)
Gross pathology:
no data
Other findings:
no data

Any other information on results incl. tables

No data.

Applicant's summary and conclusion

Executive summary:

20 male rats were whole body exposed to 590 mg/m³ or 850 mg/m³ (analytical) trimethylolpropane for 4 hours and observed for 14 days. Nominal concentrations were 2.6 und 5 g/m³. The substance was disolved in ethanol/lutrol (1:1) and dynamically sprayed into an inhalation apparatus. No mortalities and no clinical signs of toxicity were reported up to and including the highest exposure level of  850 mg/m³.The LC50 value could not be determined exactly and is supposed to be > 850 mg/m³.

(Bayer AG, 1965).