Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 266-028-2 | CAS number: 65996-93-2 The residue from the distillation of high temperature coal tar. A black solid with an approximate softening point from 30°C to 180°C (86°F to 356°F). Composed primarily of a complex mixture of three or more membered condensed ring aromatic hydrocarbons.
Endpoint summary
Administrative data
Description of key information
No experimental repeated-dose data is available on pitch itself. A structure-related coal-tar material produced no particular, treatment-related toxicity in male and female mice receiving the test material in the feed for up to 6 months. The NOAEL, 0.5 % in the diet, is estimated to correspond to approximately 400 mg/kg bw/d. Early not verifiable reports indicate that young pigs may have a significant lower tolerance to ingested coal-tar pitch or coal tar than the adult animals.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEL
- 400 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Additional information
Apart from one oral study of limited significance in pigs, no repeated-dose toxicity studies with pitch addressing effects other than carcinogenicity have been located. The subchronic feeding study in mice with coal-tar material (compared to pitch a worst case) indicates that more marked toxicity following long-term exposure to pitch is unlikely to occur.
Tars and pitches constitute a family of products that result from different distillation steps of coal (condensation products and distillation residues). Depending on distillation step and distillation temperature, constituents of the products and their portions are variable. But major components of all the distillation products and residues are condensed ring aromatic hydrocarbons in varying composition (i.e. polynuclear aromatic hydrocarbons). Major toxicological effects of these products will primarily be caused by the PAH fraction in the respective substances. Especially for toxicological endpoints that fall into the toxicological action profile of PAH, it is justified to use related tars and pitches as supporting substances to characterise potential effects of pitch, coal tar, high temp.
Repeated dose toxicity: via oral route - systemic effects (target organ) digestive: liver
Justification for classification or non-classification
Pitch is not classifiable, as there was no evidence for specific target-organ effects at doses lower than 100 mg/kg bw/d (test material: coal tar).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Route: .live1