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Physical & Chemical properties

Water solubility

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Description of key information

The water solubility was measured as 409.5 g/L

Key value for chemical safety assessment

Water solubility:
409.5 g/L
at the temperature of:
20 °C

Additional information

Two studies are available. In the key study [Lammens M & Rottiers A (2002)] a saturated aqueous solution, based on visual observation, was prepared by mixing 10 g of lyophilised test substance with 15 mL of deionised water. This mixture was stirred for 24 hours at room temperature followed by centrifugation at 2500 rpm to separate undissolved solids from the aqueous phase. The concentration of the substance dissolved in the aqueous phase was analysed using a simplified DBAS method. The water solubility of the substance was 409.5 g/L. No information is given in the report on stability of the lyophilised substance, but the result is in line with actual concentrations of amine oxide achieved during routine manufacturing and is considered to be reliable.

In the second study, the water solubility of a sample of freeze-dried substance was measured [Younis S (2010)]. The water solubility was reported as 12.46 g/L, far below the expected concentration. In addition, it was noted that the pH of the solution was > 10, whereas standard solutions have a pH around 8.5. Subsequent analysis of a sample of the freeze-dried material showed that it had degraded in part to the free amine.