Registration Dossier
Registration Dossier
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EC number: 201-550-6 | CAS number: 84-66-2
Endpoint summary
Administrative data
Description of key information
Additional information
Acute toxicity to fresh water fish has been investigated with a number of species. In rainbow trout, under flow through conditions, the 96 hour LC50 was 12 mg/L and the NOEC was 1.9 mg/L. In bluegill, under flow through conditions, the 96 hour LC50 was 22 mg/L and the NOEC was <3.3 mg/L. In fathead minnmow, under both static and flow through conditions, the 96 hour LC50 was 17 mg/L and the NOEC was 3.0 mg/L or less. Acute toxicity to fish has also been investigated in a marine species, sheephead minnow, under flow through conditions. The 96 hour LC50 was 29 mg/L and the NOEC was 10 mg/L. The effects of diethyl phthalate have been studied in adult male carp (Cyprinus carpio) by exposing them for 28 days. Metabolic enzymes and bioaccumulation were studied at weekly intervals. Behavioural changes were noted at the highest concentration examined. Acid phosphatase, aspartate aminotransferase and alanine aminotransferase activity was reduced and alkaline phosphatase activity was increased.
Acute toxicity to daphnia has been investigated in accordance with EPA test methods. The 48 hour LC50 was 90 mg/L and the NOEC was 43 mg/L.A 21 -day chronic study has been undertaken in Dapnia magna. Under the conditions of the study the NOEC for survival and reproduction of daphnids exposed to a mean measured concentration of 25 mg/l were comparable to the survival & reproduction of daphnids in the control group.Another chronic study in Dapnia magna has been reported in the literature, a NOEC for survival and reproduction of daphnids exposed to a nominal concentration of 13 mg/L being described.
Toxicity to aquatic algae has been investigated in accordance with DIN methods. The 72 hour EC50, based on biomass, was 23 mg/L and, based on growth rate, was 45 mg/L. A second study, following EPA test methods and with the exposure period extended to 8 days, determined an EC50, based on cell numbers, of 30.3 mg/L. In accordance with ECHA guidance oninformation requirements and chemical safety assessment,Chapter R.7b: Endpoint specific guidance, theErC50 endpoint is used in DNEL derivation. This is because use of values based on biomass cannot be applied to an analysis of results from a system in exponential growth without logarithmic transformation.
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