Registration Dossier

Environmental fate & pathways

Hydrolysis

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

A base-catalysed second-order hydrolysis rate constant (Kb) of 0.0564 L/(mol-sec) at 25 deg C was estimated using a structure estimation method.
This corresponds to half-lives of 3.90 years at pH 7 and 142.3 days at pH 8.

Key value for chemical safety assessment

Half-life for hydrolysis:
142.3 d
at the temperature of:
25 °C

Additional information

In accordance with REACH Regulation 1907/2006, Annex VIII, Column 2 hydrolysis as a function of pH does not need to be determined as the substance is readily biodegradable.

Anyway the stability of the substance against hydrolysis has been calculated using the following software tools:

SPARC v4.6

A base-catalysed second-order hydrolysis rate constant (Kb) of 0.0564 L/(mol-sec) at 25 deg C was estimated using a structure estimation method.

This corresponds to half-lives of 3.90 years at pH 7 and 142.3 days at pH 8.

HYDROWIN v2.00

A base-catalysed second-order hydrolysis rate constant of 0.0755 L/(mol-sec) at 25 degC was estimated using a structure estimation method.

This corresponds to half-lives of 2.9 years at pH 7 and 106.2 days at pH 8.

SPARC data was selected because not all structure fragments on diethyl phthalate are available from the fragment library included in HYDROWIN.