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Toxicological information

Toxicity to reproduction: other studies

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Administrative data

Endpoint:
toxicity to reproduction: other studies
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Review paper published in peer reviewed journal

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Unnamed
Year:
2000
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2002

Materials and methods

GLP compliance:
not specified
Type of method:
in vivo

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
other: Crl (WI) BR
Sex:
female
Details on test animals and environmental conditions:
no data

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
peanut oil
Duration of treatment / exposure:
once/day
Frequency of treatment:
daily
Duration of test:
3d
Doses / concentrations
Remarks:
Doses / Concentrations:
0, 50, 150 & 500 mg/kg/day
Basis:
nominal conc.
No. of animals per sex per dose:
10
Control animals:
yes, concurrent vehicle
other: single dose of 0.4 mg/kg B oestradiol as a positive control

Results and discussion

Any other information on results incl. tables

There were no treatment related effects on clinical observations or body weights. Uterus weight was also unaffected by treatment with DEP while the positive control produced a significant effect on uterine weight.

Applicant's summary and conclusion