Registration Dossier
Registration Dossier
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EC number: 228-408-6 | CAS number: 6259-76-3
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
No data are available for the toxicity to microorganisms of hexyl salicylate.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 100 mg/L
Additional information
No data has been generated to fulfil this data requirement. However, a biodegradation study with hexyl salicylate was conducted according to OECD guideline 301F with a nominal concentration of 100 mg/L. Under the conditions of the test, hexyl salicylate underwent 91 % biodegradation after 28 days. Biodegradation reached 82 % at the end of the 10-day window (days 2 to 12).
Thus, hexyl salicylate should be regarded as readily biodegradable according to this test.
At the concentration used in the test (100 mg/L), hexyl salicylate is not inhibitory to the micro-organisms.
In the absence of toxicity study conducted according to OECD guideline 209 the ECHA guidance document, Chapter R7.8.16.1 states the following: “The assumption that the substance under investigation is not inhibitory to the micro-organisms when dosed in the test system is implicit in ready biodegradability testing (i.e. ... OECD 301F). If a compound degrades well in a ready biodegradability test, or does not inhibit the degradation of a positive control at a certain concentration, this concentration can be used as a NOEC value”.
Therefore it is considered appropriate to set the NOEC for this endpoint as 100 mg/L.
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