Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 228-408-6 | CAS number: 6259-76-3
No additional information
In this study, isoamyl salicylate, was examined for its ability to induce toxicity following repeated exposure for a period of 13 weeks. The test substance was administered to male and female Wistar rats via oral administration in the diet at dose levels of 0, 50, 500 and 5000 ppm. Observations included mortality, food and water consumption, body weight and body weight gain, haematology, urinalysis, histopathological examinations and an examination of organ weights. One mortality was observed in the top dose level of 5000 ppm. There was a decrease in weight gain at the highest dietary level accompanied by a reduced food intake, but a paired-feeding study showed that this was due to the diet’s unpalatability. The females given the highest dietary level drank more water than the controls and produced slightly greater volumes of more dilute urine. The relative kidney weight was increased in rats on the 500 and 5000 ppm levels without any histopathological changes. It is concluded that isoamyl salicylate was exerting a mildly nephrotoxic effect. The relative liver weight was increased at the highest level of feeding but there were no other effects attributable to treatment. Under the conditions of this study, the no observed adverse effect level (NOAEL) was 500 ppm (~50 mg/kg bw/d).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again