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EC number: 228-408-6 | CAS number: 6259-76-3
Fertility of pairs during continuous breeding
In this NTP study, groups of CD-1 Mice were gavaged with methyl salicylate (in corn oil) at dose levels of 100, 250 or 500 mg/kg bw/d during the 7-day pre-mating period, a 14-week cohabitation period and 3 for weeks thereafter. A significant decrease in the average number of litters and a lower proportion of pups born alive were seen at 500 mg/kg bw/d. Dose-related decreases were found in average litter size and average pup weight with the decreases being statistically significant at 500 mg/kg bw/d and marginally significant at 250 mg/kg bw/d. A reproductive NOAEL of 100 mg/kg bw/d is therefore determined for this study.
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