Benzenesulfonic acid, C10-13-alkyl derivs., calcium salt

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Jan. 12, 1977 - Feb. 16, 1977

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study performed similarly to OECD guidelines.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Report date:

1977

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: W.S. Spector, Handbook of Toxicology

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Benzenesulfonic acid, C10-13-alkyl derivs., calcium salts

IUPAC Name:

Benzenesulfonic acid, C10-13-alkyl derivs., calcium salts

Test animals

Species:

rat

Strain:

other: SPF-Wistar

Sex:

female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 92-111 g
- Fasting period before study: 16 hrs
- Housing: plastic cages
- Diet (e.g. ad libitum): Haltungsdiat ALTROMIN 1324, ad libitum
- Water (e.g. ad libitum): ad libitum

IN-LIFE DATES: From: Jan. 12, 1977 To: Feb. 16, 1977

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

MAXIMUM DOSE VOLUME APPLIED: 25% aqueous solution

Doses:

2500, 3200, 5000, 6300 mg/kg

No. of animals per sex per dose:

10

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: weighed weekly
- Necropsy of survivors performed: yes

Statistics:

LD50 was determined using Probit Analysis (method of Linder and Weber), confidence limits were computed using Cavalli-Sforza.

Results and discussion

Effect levels

Sex:

female

Dose descriptor:

LD50

Effect level:

4 445 mg/kg bw

Based on:

act. ingr.

95% CL:

3 913 - 5 051

Mortality:

Animals that died, died 1-3 days after exposure.

Clinical signs:

other: Animals that died exhibited respiratory distress, stumbling, and lethargy prior to expiring.

Gross pathology:

No abnormal observations in any animals.

Any other information on results incl. tables

Acute Oral Toxicity in Female Rats

Dose (mg/kg)	Mortality (No. of Animals)
2500	0
3200	1
5000	6
6300	10

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The test substance is weakly toxic via oral exposure but only at doses exceeding the limit dose.

Executive summary:

Groups of 10 female rats were exposed by oral gavage to doses of 2500, 3200, 5000, and 6300 mg/kg of test substance. The animals were then monitored for the 14 days for mortality, and weighed weekly. The LD50 was determined to be 4445 mg/kg. Surviving animals showed no effects.