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REACH

Nitrobenzene

EC number: 202-716-0 | CAS number: 98-95-3

Life Cycle description
Uses advised against

Toxicological information

Endpoint summary

Administrative data

Description of key information

Rat Oral LD50 study (10 rats per sex per group)

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Dose descriptor:: LD50
Value:: 588 mg/kg bw

Additional information

Justification for classification or non-classification

As the LD50 value in rats was between 200 and 2000 mg/kg bw (588 mg/kg bw) under normal circumstances this substance would be classified as Harmful according to the DSD, Or Category 4 according to GHS). However because nitrobenzene causes methaemoglobinemia the common approach is to apply stronger classification and labeling of R 23,24,25 (toxic by inhalation in contact with skin and if swallowed) which was officially confirmed in 1995 (implemented in the 22. ATP).

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