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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Excretion of p-Nitrophenol and p-Aminophenol in the urine of a patient exposed to nitrobenzene.
Author:
Ikeda, M. and Kitta, A.
Year:
1964
Bibliographic source:
Brit. J. Industr. Med. 21, 210-213

Materials and methods

Objective of study:
metabolism
Principles of method if other than guideline:
Five adult Wistar rats were exposed to nitrobenzene vapour (0.13 mg/L) for 8 hours. Urinary levels of p-nitrophenol and p-aminophenol were determined using the method of Brodie and Axelrod (1948) after 24, 48 and 72 hours.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Nitrobenzene
EC Number:
202-716-0
EC Name:
Nitrobenzene
Cas Number:
98-95-3
Molecular formula:
C6H5NO2
IUPAC Name:
nitrobenzene
Details on test material:
- Name of test material (as cited in study report): nitrobenzene
- Analytical purity: no data
Radiolabelling:
no

Test animals

Species:
rat
Strain:
Wistar
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Vehicle:
not specified
Duration and frequency of treatment / exposure:
single treatment for 8 hours
Doses / concentrations
Remarks:
Doses / Concentrations:
0.13 mg/L (25 ppm)
No. of animals per sex per dose / concentration:
5
Control animals:
no

Results and discussion

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
The metabolites p-nitrophenol and p-aminophenol of nitrobenzene were identified and quantified.

Any other information on results incl. tables

Urinary levels of p-nitrophenol (p-aminophenol) (µmoles/day and rat) were ca. 1800 (1200) after 24 hours, ca. 500 (both) after 48 hours and 0 (both) after 72 hours.

Applicant's summary and conclusion