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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Principles of method if other than guideline:
Two white rabbits (New Zealand) were trated with 0.1 ml nitrobenzene. The test substance was not removed. Observation period was 7 days.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Nitrobenzene
EC Number:
202-716-0
EC Name:
Nitrobenzene
Cas Number:
98-95-3
Molecular formula:
C6H5NO2
IUPAC Name:
nitrobenzene
Details on test material:
- Name of test material (as cited in study report): nitrobenzene
- Analytical purity: no data

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL
Duration of treatment / exposure:
The test substamce remained in the conjunctival sac.
Observation period (in vivo):
24h, 48h, 72h and 7 days
Number of animals or in vitro replicates:
2

Results and discussion

In vivo

Results
Irritation parameter:
other: eye irritation
Basis:
animal #2
Remarks:
rabit
Time point:
other: 7 days
Score:
0

Any other information on results incl. tables

No reaction was observed.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information