Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 202-716-0 | CAS number: 98-95-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- Two white rabbits (New Zealand) were trated with 0.1 ml nitrobenzene. The test substance was not removed. Observation period was 7 days.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Nitrobenzene
- EC Number:
- 202-716-0
- EC Name:
- Nitrobenzene
- Cas Number:
- 98-95-3
- Molecular formula:
- C6H5NO2
- IUPAC Name:
- nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): nitrobenzene
- Analytical purity: no data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL - Duration of treatment / exposure:
- The test substamce remained in the conjunctival sac.
- Observation period (in vivo):
- 24h, 48h, 72h and 7 days
- Number of animals or in vitro replicates:
- 2
Results and discussion
In vivo
Results
- Irritation parameter:
- other: eye irritation
- Basis:
- animal #2
- Remarks:
- rabit
- Time point:
- other: 7 days
- Score:
- 0
Any other information on results incl. tables
No reaction was observed.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
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