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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data published in peer reviewed literature.

Data source

Reference
Reference Type:
publication
Title:
No information
Author:
Stewart et al.
Year:
1970
Bibliographic source:
Data published in Arch Env Hlth, 20, 218-224

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
1-methoxypropan-2-ol
EC Number:
203-539-1
EC Name:
1-methoxypropan-2-ol
Cas Number:
107-98-2
Molecular formula:
C4H10O2
IUPAC Name:
1-methoxypropan-2-ol

Results and discussion

Applicant's summary and conclusion

Executive summary:

Inhalation experiments with increasing concentrations from 50-1000 ppm (2050 ppm in one case). Duration of exposure was up to 7 h at concentrations up to 250 ppm and up to 2 h at concentrations up to 2050 ppm. 10 ppm was the level at which the substance was noticeable. Above 100 ppm people had a temporarily smell-irritation, after 1-2 h exposure time the eyes were slightly irritated. At 300 ppm people had mild eye- and nose irritations within 5 minutes and after 1 h irritations were only hardly bearable. 750 ppm was scored as very strongly irritating. At 1000 ppm indications of a CNS-depression were recognized. Breath analysis data showed that PM was rapidly excreted via the lungs. The human volunteers all experienced a rapid development of odor tolerance. Hence, unless prompt action is taken when objectionable odor is experienced, it cannot be relied upon to prevent exposures that might be hazardous. However, because the odor is readily detected and is objectionable PM vapors are considered to have adequate warning properties, if needed. Neurologic, clinical, chemical and general medical studies didn't show any significant abnormalities.