Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Well conducted study, no guideline applicable.

Data source

Reference
Reference Type:
publication
Title:
Propylene glycol monomethyl ether (PGME) occupational exposure - 1. Biomonitoring by analysis of PGME in urine.
Author:
Devanthéry, A. Dentan, A. Berode, M. and Droz, P.-O.
Year:
2000
Bibliographic source:
Data published in Arch. Occup. Environ. Health, 73, 311-315.

Materials and methods

Type of study / information:
Type of experience: Human

Test material

Constituent 1
Chemical structure
Reference substance name:
1-methoxypropan-2-ol
EC Number:
203-539-1
EC Name:
1-methoxypropan-2-ol
Cas Number:
107-98-2
Molecular formula:
C4H10O2
IUPAC Name:
1-methoxypropan-2-ol

Results and discussion

Applicant's summary and conclusion

Executive summary:

There was a statistically significant correlation between measurements of external exposure and PGME in urine. Highest concentration of PGME in urine was 7.78 mg/l. After exposure the urinary levels decreased rapidly. The fraction of conjugated PGME was rather constant between 30-65%.

Urine of three workers who were occupationally exposed to PGME was analyzed for free and conjugated alpha PGME concentrations by solid phase extraction and GC/FID analysis. Air concentration of PGME ranged from 20 to 40 ppm.