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Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Well conducted study, no guideline applicable.

Data source

Reference
Reference Type:
publication
Title:
Propylene glycol monomethyl ether (PGME) occupational exposure - 1. Biomonitoring by analysis of PGME in urine.
Author:
Devanthéry, A. Dentan, A. Berode, M. and Droz, P.-O.
Year:
2000
Bibliographic source:
Data published in Arch. Occup. Environ. Health, 73, 311-315.

Materials and methods

Type of study / information:
Type of experience: Human

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Applicant's summary and conclusion

Executive summary:

There was a statistically significant correlation between measurements of external exposure and PGME in urine. Highest concentration of PGME in urine was 7.78 mg/l. After exposure the urinary levels decreased rapidly. The fraction of conjugated PGME was rather constant between 30-65%.

Urine of three workers who were occupationally exposed to PGME was analyzed for free and conjugated alpha PGME concentrations by solid phase extraction and GC/FID analysis. Air concentration of PGME ranged from 20 to 40 ppm.