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EC number: 218-645-3 | CAS number: 2210-79-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to the O.E.C.D. test guideline 404 with GLP compliance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2,3-epoxypropyl o-tolyl ether
- EC Number:
- 218-645-3
- EC Name:
- 2,3-epoxypropyl o-tolyl ether
- Cas Number:
- 2210-79-9
- Molecular formula:
- C10H12O2
- IUPAC Name:
- oxirane
- Reference substance name:
- Oxirane, 2-[(2-methylphenoxy)methyl]-
- IUPAC Name:
- Oxirane, 2-[(2-methylphenoxy)methyl]-
- Details on test material:
- As per IUCLID Sections 1.1. 1.2. and 4.1.
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- The animals were acquired from Kleintierfarm Madoerin AG CR 4414 Fuellinsdorf / Switzerland were 14-15 weeks old and weighed 2.4-2.6 Kg. The animals were maintained Individually in stainless steel cages equipped with an automatic cleaning and drinking system (Dipl. Ing. W. Ehret GmbH, Versuchstiertechnik, 0—7830 Emmendingen / FRG). The rabbits were allowed access to Pelleted standard Kliba 341, rabbit maintenance diet (°Kliba, Klingentalmuehle AG, 4303 Kaiseraugst, Switzerland) and water ad libitum. The animal room was air-conditioned with 10—15 air changes per hour and hourly monitored environment with temperature 20+—3 degrees centigrade, relative humidity 40—70%, 12 hours
artificial fluorescent light/12 hours dark/light period. The animals were acclimated to laboratory conditions for four days before being placed on-study.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 mL
- Duration of treatment / exposure:
- 4 hr
- Observation period:
- 7 days
- Number of animals:
- 3
- Details on study design:
- Approximately 24 hours before treatment, the dorsal fur was shaved with an electric clipper, exposing an area of approximately 100 square centimeters (10 cm x 10 cm). On test day 1, 0.5 ml of the test substance was applied to the intact skin of the shaved area. It was covered with a 3.0 cm x 3.0 cm patch of surgical gauze. The gauze was covered with a semi-occlusive dressing. The dressing was wrapped around the abdomen and anchored with an elastic bandage.
Four hours after the application, the dressing was removed and the skin was flushed with lukewarm tap water. The skin reaction was assessed at 1, 24, 48 and 72 hours and at 7 days Intervals. The skin reactions were accessed according to O.E.C.D. Test Guideline no. 404.
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: Seven day observation period.
- Score:
- ca. 1.2
- Reversibility:
- fully reversible within: 7 days
- Irritant / corrosive response data:
- Local signs (mean 1 hour to 7 days) consisted of grade 0.67 erythema and grade 0.27 edema.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The Primary Irritation Index of 1.2 suggests that the test substance is a "mild irritant" of the skin. However, the study data does not support Classification and Labeling as a skin irritant.
- Executive summary:
The test substance, 2,3 -epoxypropyl o-tolyl ether was evaluated for skin irritation potential in an O.E.C.D. Test Guideline no 404 study. The Primary Irritation Index of 1.2 observed in the suggests that the test substance is a "mild irritant" of the skin. However, the study data does not support Classification and Labeling as a skin irritant.
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