Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

Under the conditions of this study, the administration of 2, 3-epoxypropyl o-tolyl ether (EPOTE) at actual dose levels up to and including 500 mg/kg/day was evaluated as negative for the induction of cII mutants in liver and testes of Big Blue® mice.

Short description of key information:
The test substance, 2,3-epoxypropyl o-tolyl ether was accessed for in vitro genotoxicity in two independent Ames/Salmonella mutation tests and an in vitro huiman lymphocyte DNA repair UDS study. Potential in vivo genotoxicity was evaluated in two mouse micronucleus (chromosome damage) studies, a male mouse dominate lethal assay and 2 MutaMouse gene-mutation assay in bone marrow, liver, skin or liver and testes.

Endpoint Conclusion: Adverse effect observed (negative)

Justification for classification or non-classification

The weight-of-evidence demonstrates that there is insufficient in vivo genotoxicity evidence to Classify and Label the test substance as a Mutagen.