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Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions
Qualifier:
equivalent or similar to
Guideline:
other: DIN 38412/11
Principles of method if other than guideline:
Method: basic method for the implementation of DIN 38412/11. Test procedure in accordance with German national standards
GLP compliance:
no
Specific details on test material used for the study:
- Name of the test item (as cited by study report): triethylene glycol
Analytical monitoring:
not specified
Test organisms (species):
Daphnia magna
Details on test organisms:
TEST ORGANISM
- Strain: IRCHA
- Method of breeding: 20 - 30 individuals / 2 L beaker
- Tap water - pH: 7.6 - 7.7
- Feed: dry algae
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h
Test temperature:
20 °C
Details on test conditions:
TEST SYSTEM
- Test vessel: 50 mL beakers
- Fill volume: 20 mL test medium
- Aeration: None
- No. of organisms per vessel: 10
- Age of test organisms: 24h
- Number of replicates: 2

TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: according to DIN 38412, part 11 (draft)

OTHER TEST CONDITIONS
- Photoperiod: 9 h light / 15 h dark cycle
Reference substance (positive control):
yes
Remarks:
potassium-dichromate
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 10 000 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility

OTHER EFFECT VALUES

- 48-h EC100 > 10000.0 mg/L

Description of key information

The 48-h EC50 value of main component triethylene glycol is > 10000 mg/L in aquatic invertebrates. With high probability the test substance is acutely not toxic to aquatic invertebrates.

Key value for chemical safety assessment

Additional information

The assessment on the short-term toxcity to aquatic invertebrates of the reaction mass of 2,2'-(ethylenedioxy)diethanol 3,6,9-trioxaundecane-1,11-diol is based on a study performed with main component triethylene glycol (CAS 112-27-6).

The acute toxicity to aquatic invertebrates of main component triethylene glycol was determined in a non-GLP study equivalent or similar to DIN 38412/11 (Bringmann & Kühn, 1982). In this study, daphnids (D. magna, 20 per treatment) were exposed to the test substance up to 10000 mg/L (test concentrations not further specified), for 48 hours under static conditions. Analytical verification of the test concentrations was not performed. No effect on mobility was observed. Based on the findings, the 48-h EC50 value was determined at > 10000 mg/L.