Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
According to BASF-internal standard
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3,6,9-trioxaundecane-1,11-diol
EC Number:
203-989-9
EC Name:
3,6,9-trioxaundecane-1,11-diol
Cas Number:
112-60-7
Molecular formula:
C8H18O5
IUPAC Name:
2,2'-[oxybis(ethane-2,1-diyloxy)]diethanol
Test material form:
liquid
Specific details on test material used for the study:
Purity about 90%

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: Mean body weight of male animals was 190 g, mean body weight of female animals was 170 g.
- Diet: A standard animal diet (Altromin R 1324, Altromin GmbH, Lage, Germany) was used; water was available ad libitum.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
10000 µL/kg
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 10 000 other: µL/kg
Based on:
test mat.
Remarks on result:
other: Equivalent to > 11240 mg/kg bw
Mortality:
none
Clinical signs:
other: no abnormalities
Gross pathology:
no abnormalities

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met