Registration Dossier

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
basic toxicokinetics in vivo
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Justification for type of information:
Additional information is available in the endpoint summaries and the read-across justification (see section 13).
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Type:
metabolism
Results:
Rat: Metabolism of the test substance by alcohol dehydrogenase can be inhibited by 4-methyl pyrazole or ethanol.
Type:
excretion
Results:
Rat: The total recovery of radioactivity was 90.6% - 98.3% of the administered dose (86.1 - 90.0% in urine).
Type:
excretion
Results:
Rabbits: At 200 or 2000 mg/kg, respectively 34.3 and 28% of the test substance was excreted unchanged.

Description of key information

Key value for chemical safety assessment

Additional information

No data are available for the test substance. McKennis (1962, cited in CIR 2006) stated, that TEG is believed to be metabolized in mammals by alcohol dehydrogenase to acidic products causing metabolic acidosis. TEG metabolism by alcohol dehydrogenase can be inhibited, e.g. by 4-methylpyrazole or ethanol.