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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report Date:
1976

Materials and methods

Principles of method if other than guideline:
According to BASF-internal standards.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Specific details on test material used for the study:
- Purity: about 90%

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals and environmental conditions:
Body weight male rabbit: 3.48 kg
Body weight female rabbit: 3.49 kg

Test system

Type of coverage:
occlusive
Preparation of test site:
other: intact or abraded
Vehicle:
unchanged (no vehicle)
Controls:
other: untreated skin of the same animal
Amount / concentration applied:
0.5 g
Duration of treatment / exposure:
20 h
Observation period:
Readings after 24 hours and 8 days
Number of animals:
2
Details on study design:
The test substance was applied to a 2.5 x 2.5 cm application site of white Vienna rabbits for 20 h under occlusive conditions. The skin was either intact or abraded. After the application time, the skin was washed with water which may have contained a mild detergent. Animals were observed for 8 days and skin changes were observed on working days. Findings were recorded after 1 min, 5 min, 15 min and 20 hours and at the end of the observation period. Findings were graded as described in OECD test guideline 404.

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
24 h
Score:
0
Irritant / corrosive response data:
After 20-hour exposure a slight reddening (ear) was observed, which was reversible within 8 days.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met