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Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2006-2007
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
Test procedure according to method of Analytical Expert Group ETAD (Ecological and Toxicological Association of Dyes and Organic Pigment Manufacturer)
Cross-reference
Reason / purpose for cross-reference:
reference to same study
Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2006-2007
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
test procedure similar to OECD 105
Reason / purpose for cross-reference:
reference to same study
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
yes
Remarks:
modified taking into account the very low solubilty of the test substance
Principles of method if other than guideline:
The method for the determination and analytical investigation is according to the method that was agreed upon at the "Analytical Experts Meeting" of ETAD (Basel) on January 12, 2005.
Type of method:
flask method
Water solubility:
14.5 µg/L
Temp.:
23 °C
pH:
ca. 7
Details on results:
The value given refers to room temperature (23-24 °C, see above) and represents the mean from 3 determinations (sigma = 3.8). Individual values were: 11.0, 14.0 and 18.6 µg/L.
Conclusions:
the test substance is practically insoluble in water(< 0.1 mg/L)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2007
Report date:
2007

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: ETAD Analytical Expert Group
Version / remarks:
method for substances with very low solubility in both, water and n-octanol
Principles of method if other than guideline:
Determination of solubility in n-octanol and calculation of log Pow with water solubility reported in section 4.8
Type of method:
estimation method (solubility ratio)
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
2,9-dichloro-5,12-dihydroquino[2,3-b]acridine-7,14-dione
EC Number:
221-424-4
EC Name:
2,9-dichloro-5,12-dihydroquino[2,3-b]acridine-7,14-dione
Cas Number:
3089-17-6
Molecular formula:
C20H10Cl2N2O2
IUPAC Name:
2,9-dichloro-5,12-dihydroquino[2,3-b]acridine-7,14-dione
Test material form:
solid: nanoform

Study design

Analytical method:
photometric method

Results and discussion

Partition coefficientopen allclose all
Key result
Type:
Pow
Partition coefficient:
0.3
Temp.:
23 °C
pH:
ca. 7
Key result
Type:
log Pow
Partition coefficient:
-0.52
Temp.:
23 °C
pH:
ca. 7
Details on results:
Pow and log Pow were calculated from solubilities in octanol (see below) and in water (see section 4.8)

Any other information on results incl. tables

The solubility in n-octanol was determined to be 4.4 µg/L at ambient temperature (23-24°C). This figure represents the mean of 3 determinations (range: 2.3 -7.1 µg/L, sigma = 2.5). The solubility in water was determined to be 14.5 µg/L (section 4.8)

These solubilities are used to calculate Pow with the following equation:

Pow = solubility in octanol / solublity in water

Pow = 4.4 µg/L / 14.5 µg/L

Pow = 0.30

log Pow = -0.52

Applicant's summary and conclusion

Conclusions:
The test item has a log Pow of -0.52.