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Diss Factsheets

Administrative data

Endpoint:
nanomaterial dustiness
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods
Remarks:
according to DIN EN 17199-3

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2020
Report date:
2020

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: DIN EN 17199-3
Version / remarks:
measurement of dustiness of bulk materials that contain or release respirable NOAA or other respirable particles - Part 3: Continuous drop method
Deviations:
yes
Remarks:
1 meaurement performed
GLP compliance:
no
Type of method:
continuous drop
Sampling:
The test material was used without further treatment (e.g. drying). 180.7 g (536 cm3) test material are used for the measurement, dosing rate: 18.7 g/min

Test material

1
Chemical structure
Reference substance name:
2,9-dichloro-5,12-dihydroquino[2,3-b]acridine-7,14-dione
EC Number:
221-424-4
EC Name:
2,9-dichloro-5,12-dihydroquino[2,3-b]acridine-7,14-dione
Cas Number:
3089-17-6
Molecular formula:
C20H10Cl2N2O2
IUPAC Name:
2,9-dichloro-5,7,12,14-tetrahydro-5,12-diazapentacene-7,14-dione
Test material form:
solid: nanoform

Results and discussion

Dustiness indexopen allclose all
Key result
Mean:
146 749.4 other: 1/mg
Remarks on result:
other: dustiness index as number of airborne particles per mg in the nanoscale (10 nm - 100 nm)
Mean:
50 033.2 other: N/cm3
Remarks on result:
other: number of airborne nanoparticles per cm3

Any other information on results incl. tables

measurement duration: 10 min

temperature: 20°C, rel. air humidity 42 %

The cleaned, almost particle-free air had a total particle count of 21 particles/cm3 in the range of 10 nm - 417 nm, the nanoscale fraction (10 - 100 nm) contained 18 particles/cm3.

table 1: summary SMPS (sanning mobility particle sizer)

Range [nm]

Mean [nm]

Concentration [N/cm3]

ICD[1/mg]

ECD[1/mg x s]

10 - 100

43.1

50033.2

146749.4

244.6

100 - 417

162.0

16723.8

49051.6

81.8

10 - 417

72.9

66757.0

195801.0

326.3

ICD: dustiness index as number of airborne particles per mg

ECD: emission rate as number of particles per mg per second

mean: average particle diameter in nm

N: number of airborne particles

table 2: summary OPS (optical particle sizer)

Range [µm]

Mean [µm]

Concentration [N/cm3]

ICD[1/mg]

ECD[1/mg x s]

0.3 - 10

5.1

2528.8

7417.0

12.4

Applicant's summary and conclusion

Executive summary:

The dusting behaviour of the test material was investigated using DIN EN 17199 -3: 2019 -12 "workplace exposure - measurement of dustiness of bulk materials that contain or release respirable nano objects and their aggregates and agglomerates or other respirable particles- Part 3: Copntinuous drop method".

The dust released by the falling test material was measured by a scanning mobility particle sizer (SMPS, 10 - 417 nm) and an optical particle sizer (3 - 10 µm). The counterflow was provided by cleaned, almost particle-free air.

The SMPS counted 66757.0 particles per cm3 (in the nanoscale (10 - 100 m) 50033.2 particles per cm3) corresponding to a dustiness index of 195801.0 particles per mg (in the nanoscale (10 - 100 nm) 146749.4 particles per mg). The mean size of the nanoparticles was 43.1 nm, the mean size of particles in the range 10 - 417 nm was 72.9 nm.

The OPS (0.3 - 10 µm) counted 2528.8 particles per cm3 corresponding to a dustiness index of 7417.0 particles per mg. The mean size of the particles was 5.1 µm.