Registration Dossier
Registration Dossier
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EC number: 203-677-2 | CAS number: 109-52-4
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- BASF-Test to assess acute toxicity in mice after intraperitoneal substance application
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Valeric acid
- EC Number:
- 203-677-2
- EC Name:
- Valeric acid
- Cas Number:
- 109-52-4
- Molecular formula:
- C5H10O2
- IUPAC Name:
- pentanoic acid
- Details on test material:
- - Name of test material (as cited in study report): Valeric acid, substance ID: 77/505
- Physical state: clear liquid
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Wiga
- Mean weight at study initiation: male: 30 g; female: 24 g
- Fasting period before study: no data
- Housing: groups of five
- Diet: ad libitum
- Water: Tap water ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C):
- Humidity (%):
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- olive oil
- Doses:
- 21.5, 100, 200, 464, 700, 2150 mg/kg bw
- No. of animals per sex per dose:
- 5 males, 5 females (200 and 700 mg/kg bw)
2 males and 2 females all other dosing groups - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily on working days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 200 - 464 mg/kg bw
- Mortality:
- 21.5 mg/kg dosing group: no death occurred
100 mg/kg dosing group: no death occurred
200 mg/kg dosing group: no death occurred
464 mg/kg dosing group: all animals died
700 mg/kg dosing group: all animals died within 7 days
2150 mg/kg dosing group: all animals died within 7 days - Clinical signs:
- dyspnoea, apathy, abdominal position, staggering, spastic gait, exsiccosis, bad general condition
- Body weight:
- normal body weight gain
- Gross pathology:
- Organs without findings
Applicant's summary and conclusion
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